Processes 2018, 6,39
overlaps will decrease the readability of the results on the metabolic network as the number of steps
increases. It is difficult to define a precise limit in size and data. Typically, the field of use of this
software consists of metabolic networks between a few steps (around 10) to less than 200 reactions,
which is probably the limit for a discriminating visualization. This is also the range of the size of
customer’s network in the literature (mainly between 10 and 50 which can already generate a very
great number of EFMs and possible solutions).
Figure 6. SVG representation of the network of Figure 1a with MetExplore, which is representative of
most of the software cited in the text. The red arrows correspond to substrates and the green ones to
products of the reactions in rectangles. The metabolites are indicated with circles.
151
overlaps will decrease the readability of the results on the metabolic network as the number of steps
increases. It is difficult to define a precise limit in size and data. Typically, the field of use of this
software consists of metabolic networks between a few steps (around 10) to less than 200 reactions,
which is probably the limit for a discriminating visualization. This is also the range of the size of
customer’s network in the literature (mainly between 10 and 50 which can already generate a very
great number of EFMs and possible solutions).
Figure 6. SVG representation of the network of Figure 1a with MetExplore, which is representative of
most of the software cited in the text. The red arrows correspond to substrates and the green ones to
products of the reactions in rectangles. The metabolites are indicated with circles.
151