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Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase,
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[PubMed]
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Mutational analysis of a membrane protein. Annu. Rev. Genet. 1990, 24, 133–170. [CrossRef][PubMed]
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& Sons, Inc.: Hoboken, NJ, USA, 2008.
44. Golan, D.; Tashjian, A.; Armstrong, E. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy;
Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2011.
45. Balasubramaniam, S.; Szanto, A.; Roach, P. Circadian rhythm in hepatic low-density-lipoprotein
(LDL)-receptor expression and plasma LDL levels. Biochem. J. 1994, 298, 39–43. [CrossRef][PubMed]
46. Lickwar, C.R.; Mueller, F.; Hanlon, S.E.; McNally, J.G.; Lieb, J.D. Genome-wide protein-DNA binding
dynamics suggest a molecular clutch for transcription factor function. Nature 2012, 484, 251–255. [CrossRef]
[PubMed]
47. Yang, W.; Swartz, J. A filter microplate assay for quantitative analysis of DNA binding proteins using
fluorescent DNA. Anal. Biochem. 2011, 415, 168–174. [CrossRef][PubMed]
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
113
34. Basu, S.; Goldstein, J.; Brown, M. Characterization of the low density lipoprotein receptor in membranes
prepared from human fibroblasts. J. Biol. Chem. 1978, 253, 3852–3856. [PubMed]
35. Shearer, K. The regulation and uptake of dietary fats. Ph.D. Thesis, University of Reading, Reading, UK, 2010.
36. Dunn, K.; McGraw, T.; Maxfield, F. Iterative fractionation of recycling receptors from lysosomally destined
ligands in an early sorting endosome. J. Cell Biol. 1989, 109, 3303–3314. [CrossRef][PubMed]
37. Panovska, J.; Tindall, M.; Wattis, J.; Byrne, H. Mathematical models of hepatic lipoprotein metabolism.
In Proceedings of the 5th Mathematics in Medicine Study Group, Oxford, UK, 12–16 September 2005.
38. Rudling, M.; Angelin, B.; Ståhle, L.; Reihnér, E.; Sahlin, S.; Olivecrona, H.; Björkhem, I.; Einarsson, C.
Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase,
and cholesterol 7α-hydroxylase mRNAs in human liver. J. Clin. Endocrinol. Metab. 2002, 87, 4307–4313.
[CrossRef][PubMed]
39. Go, G.; Mani, A. Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis.
Yale J. Biol. Med. 2012, 85, 19–28. [PubMed]
40. Foundation, F.H. Familial Hypercholesterolaemia. 2018. Available online: https://thefhfoundation.org
(accessed on 6 June 2018).
41. Dammerman, M.; Breslow, J. Genetic basis of lipoprotein disorders. Circulation 1995, 91, 505–512. [CrossRef]
[PubMed]
42. Hobbs, H.; Russell, D.; Brown, M.; Goldstein, J. The LDL receptor locus in familial hypercholesterolemia:
Mutational analysis of a membrane protein. Annu. Rev. Genet. 1990, 24, 133–170. [CrossRef][PubMed]
43. Iman, R. Latin Hypercube Sampling. In Encyclopedia of Quantitative Risk Analysis and Assessment; John Wiley
& Sons, Inc.: Hoboken, NJ, USA, 2008.
44. Golan, D.; Tashjian, A.; Armstrong, E. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy;
Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2011.
45. Balasubramaniam, S.; Szanto, A.; Roach, P. Circadian rhythm in hepatic low-density-lipoprotein
(LDL)-receptor expression and plasma LDL levels. Biochem. J. 1994, 298, 39–43. [CrossRef][PubMed]
46. Lickwar, C.R.; Mueller, F.; Hanlon, S.E.; McNally, J.G.; Lieb, J.D. Genome-wide protein-DNA binding
dynamics suggest a molecular clutch for transcription factor function. Nature 2012, 484, 251–255. [CrossRef]
[PubMed]
47. Yang, W.; Swartz, J. A filter microplate assay for quantitative analysis of DNA binding proteins using
fluorescent DNA. Anal. Biochem. 2011, 415, 168–174. [CrossRef][PubMed]
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
113