Processes 2018, 6, 134
Appendix F. Full Model Results for Statin Application
Figure A6. A simulation showing the effect of statin therapy on our integrated model of cholesterol
metabolism. Here 11 doses are applied over a seven day period starting at approximately t = 10 h.
References
1.
O’Brien, J.; Sampson, E. Lipid composition of the normal human brain: Gray matter, white matter, and myelin.
J. Lipid Res. 1965, 6, 537–544. [PubMed]
2.
Jousilahti, P.; Vartiainen, E.; Tuomilehto, J.; Puska, P. Sex, age, cardiovascular risk factors, and coronary heart
disease A prospective follow-up study of 14,786 middle-aged men and women in Finland. Circulation 1999,
99, 1165–1172. [CrossRef][PubMed]
3.
Turley, S.; Dietschy, J. The intestinal absorption of biliary and dietary cholesterol as a drug target for lowering
the plasma cholesterol level. Prev. Cardiol. 2003, 6, 29–64. [CrossRef][PubMed]
4.
Goldstein, J.; Brown, M.; Anderson, R.; Russell, D.; Schneider, W. Receptor-mediated endocytosis:
Concepts emerging from the LDL receptor system. Annu. Rev. Cell Biol. 1985, 1, 1–39. [CrossRef]
[PubMed]
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Grundy, S. Inflammation, metabolic syndrome, and diet responsiveness. Circulation 2003, 108, 126–128.
[CrossRef][PubMed]
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Gowdy, K.; Fessler, M. Emerging roles for cholesterol and lipoproteins in lung disease. Pulm. Pharmacol. Ther.
2013, 26, 430–437. [CrossRef][PubMed]
7.
Bermudes, A.; de Carvalho, W.; Dietist, P.; Muramoto, G.; Maranhão, R.; Delgado, A. Changes in lipid
metabolism in pediatric patients with severe sepsis and septic shock. Nutrition 2018, 47, 104–109. [CrossRef]
[PubMed]
8.
Lagrost, G.; Grosjean, S.; Masson, D.; Deckert, V.; Gautier, T.; Debomy, F.; Vinault, S.; Jeannin, A.; Labbé, J;
Bonithon-Kopp, C. Low preoperative cholesterol level is a risk factor of sepsis and poor clinical outcome
in patients undergoing cardiac surgery with cardiopulmonary bypass. Crit. Care Med. 2014, 42, 1065–1073.
[CrossRef][PubMed]
9.
Paalvast, Y.; Kuivenhoven, J.; Groen, A. Evaluating computational models of cholesterol metabolism.
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111
Appendix F. Full Model Results for Statin Application
Figure A6. A simulation showing the effect of statin therapy on our integrated model of cholesterol
metabolism. Here 11 doses are applied over a seven day period starting at approximately t = 10 h.
References
1.
O’Brien, J.; Sampson, E. Lipid composition of the normal human brain: Gray matter, white matter, and myelin.
J. Lipid Res. 1965, 6, 537–544. [PubMed]
2.
Jousilahti, P.; Vartiainen, E.; Tuomilehto, J.; Puska, P. Sex, age, cardiovascular risk factors, and coronary heart
disease A prospective follow-up study of 14,786 middle-aged men and women in Finland. Circulation 1999,
99, 1165–1172. [CrossRef][PubMed]
3.
Turley, S.; Dietschy, J. The intestinal absorption of biliary and dietary cholesterol as a drug target for lowering
the plasma cholesterol level. Prev. Cardiol. 2003, 6, 29–64. [CrossRef][PubMed]
4.
Goldstein, J.; Brown, M.; Anderson, R.; Russell, D.; Schneider, W. Receptor-mediated endocytosis:
Concepts emerging from the LDL receptor system. Annu. Rev. Cell Biol. 1985, 1, 1–39. [CrossRef]
[PubMed]
5.
Grundy, S. Inflammation, metabolic syndrome, and diet responsiveness. Circulation 2003, 108, 126–128.
[CrossRef][PubMed]
6.
Gowdy, K.; Fessler, M. Emerging roles for cholesterol and lipoproteins in lung disease. Pulm. Pharmacol. Ther.
2013, 26, 430–437. [CrossRef][PubMed]
7.
Bermudes, A.; de Carvalho, W.; Dietist, P.; Muramoto, G.; Maranhão, R.; Delgado, A. Changes in lipid
metabolism in pediatric patients with severe sepsis and septic shock. Nutrition 2018, 47, 104–109. [CrossRef]
[PubMed]
8.
Lagrost, G.; Grosjean, S.; Masson, D.; Deckert, V.; Gautier, T.; Debomy, F.; Vinault, S.; Jeannin, A.; Labbé, J;
Bonithon-Kopp, C. Low preoperative cholesterol level is a risk factor of sepsis and poor clinical outcome
in patients undergoing cardiac surgery with cardiopulmonary bypass. Crit. Care Med. 2014, 42, 1065–1073.
[CrossRef][PubMed]
9.
Paalvast, Y.; Kuivenhoven, J.; Groen, A. Evaluating computational models of cholesterol metabolism.
Biochim. Biophys. Acta 2015, 1851, 1360–1376. [CrossRef][PubMed]
111