TABLe 8.3
Selection.of.Patents.and.Patent.Applications.Related.to.the.Use.of.Bacterial.Cellulose.
in.Fabrication.of.Wound.Dressings
Patent/Application
Patent Description
Assignee
Number
Filed
Cellulose.membrane.and.
University.of.
U.S..Patent.876,400
June.1997
method.for.manufacture.
Western.Ontario,.
thereof
Canada
Microbial.cellulose.wound.
Lohmann.&.
U.S..Patent.7,390,499
April.2002
dressing.for.treating.
Rauscher.GmbH
U.S..Patent.7,704,523
April.2003
chronic.wounds
U.S..Patent.7,709,021
December.2003
Microbial-derived.cellulose.
Xylos.Corporation
U.S..Patent.
January.2003
amorphous.hydrogel.
application.
wound.dressing
10,345,394
Microbial.cellulose.wound.
Xylos.Corporation
U.S..Patent.
June.2004
dressing.for.treating.
application.
chronic.wounds
10,864,804
Nanosilver-coated.bacterial.
Axcelon.
U.S..Patent.
April.2007
cellulose
Biopolymers.
application.
Corporation
12,226,669
Photoactivated.antimicrobial. Lotec,.Inc.,.DBA.
U.S..Patent.
February.2008
wound.dressing.and.
Vesta.Sciences.Inc.,.
application.
method.relating.thereto
UT-Batelle,.LLC
12,034,629
Oxidized.microbial.cellulose. Xylos.Corporation
U.S..Patent.7,709,631
January.2007
and.use.thereof
A.method.of.modification.of. Technical.University. PL.Patent.
June.2010
bacterial.cellulose.
of.Lodz,.Poland
application.392,480
membranes
162
Bacterial Cellulose
The.dominant.advantages.of.BNC,.such.as.biocompatibility,.are.discussed.
elsewhere.in.this.book..Because.BNC.is.not.digested.by.body.fluids,.. neither.
cellulose.fibers.nor.products.of.their.degradation.are.released.into.the.wound;.
this.has.also.been.proven.by.microscopic.observations.(Mendes.et al..2009)..
Furthermore,. when. bacterial. cellulose. is. brought. into. contact. with. blood,.
it  attenuates. thrombogenicity. (Fink. et. al.. 2010).. This. advantageous. feature.
is. rather. unique,. and. therefore. the. development. of. nonthrombogenic. biomaterials.has.been.an.objective.of.intensive.research.in.recent.decades.
The.high.water-holding.capacity.of.BNC.dressings.enables.maintenance.of.
a.moist.environment.at.the.wound.surface..This.in.turn.prevents.additional.
tissue.loss.from.dehydration..Humidity.is.known.to.stimulate.the.action.of.
lytic. enzymes,. which. remove. residual. debris. in. the. early. stages. of. wound.
healing,.and.speeds.up.restoration.of.the.wounded.tissue.to.its.normal.state.
BNC. dressings. are. absorbable. and. capable. of. donating. moisture. while.
simultaneously. absorbing. exudates.. It. is. of. particular. importance. in. the.
treatment. of. chronic. wounds,. as. their. exudates. are. known. to. display. relatively. high. activity. for. proteolytic. enzymes,. which. are. responsible. for.