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Notch Signaling in Early Embryogenesis
FIGURE 7.1 The canoncial Notch signaling device, expression of Notch receptors and ligands during early embryogenesis, and components of the Notch pathway during somitogenesis in Xenopus. (A) Simplifed scheme showing the canonical Notch signaling pathway
in vertebrates. CoA, co-activators; CoR, co-repressors; see additional abbreviations in the main text. (B) Modes of action of Notch
signaling. (C) Early expression patterns of Notch receptors and ligands in Xenopus. References for building the expression domain’s
diagrams (left) are listed in Table 7.1. Quantitative expression profles from Xenopus laevis (average TPM values from Taira and Ueno
samples) were plotted with RefSeq data extracted from (Session et al., 2016) (right column). Abbreviations for Figure 7.1C and Figure
7.2: a, anterior; An, animal; anb, anterior neural border; anf, anterior neural fold; ang, anterior neural groove; angb, anterior neural
groove border (prospective ventral forebrain and ventral midbrain) (Lahaye et al., 2002); anp, anterior neural plate; anr, anterior neural
ridge; (d), deep layer; dbl, dorsal blastopore lip; dmz, dorsal marginal zone; ee, epidermal ectoderm; ego, early gastrula organizer; fp,
foor plate; i, intermediate domain of primary neurogenesis; imz, involuting marginal zone; l, lateral domain of primary neurogenesis;