75
Wnt Signaling in Tissue Differentiation
Pandur, P., Lasche, M., Eisenberg, L.M., Kuhl, M., 2002. Wnt11 activation of a non-canonical Wnt signalling pathway is
required for cardiogenesis. Nature 418, 636–641.
Penzo-Mendez, A., Umbhauer, M., Djiane, A., Boucaut, J.C., Riou,
J.F., 2003. Activation of Gbetagamma signaling downstream
of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus
gastrulation. Dev Biol 257, 302–314.
Peters, J.M., McKay, R.M., McKay, J.P., Graff, J.M., 1999. Casein
kinase I transduces Wnt signals. Nature 401, 345–350.
Piccolo, S., Dupont, S., Cordenonsi, M., 2014. The biology of
YAP/TAZ: Hippo signaling and beyond. Physiol Rev 94,
1287–1312.
Podleschny, M., Grund, A., Berger, H., Rollwitz, E., Borchers, A.,
2015. A PTK7/Ror2 Co-receptor complex affects Xenopus
neural crest migration. PLoS One 10, e0145169.
Polevoy, H., Gutkovich, Y.E., Michaelov, A., Volovik, Y., Elkouby,
Y.M., Frank, D., 2019. New roles for Wnt and BMP signaling
in neural anteroposterior patterning. EMBO Rep 20.
Prieve, M.G., Moon, R.T., 2003. Stromelysin-1 and mesothelin
are differentially regulated by Wnt-5a and Wnt-1 in C57mg
mouse mammary epithelial cells. BMC Dev Biol 3, 2.
Ramakrishnan, A.-B., Sinha, A., Fan, V.B., Cadigan, K.M., 2018.
The Wnt transcriptional switch: TLE removal or inactivation? BioEssays 40.
Rasmussen, J.T., Deardorff, M.A., Tan, C., Rao, M.S., Klein, P.S.,
Vetter, M.L., 2001. Regulation of eye development by frizzled signaling in Xenopus. Proc Natl Acad Sci U S A 98,
3861–3866.
Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H.,
Moerer, P., van de Wetering, M., Destree, O., Clevers, H., 1998.
The Xenopus Wnt effector XTcf-3 interacts with Grouchorelated transcriptional repressors. Nature 395, 608–612.
Rothbacher, U., Laurent, M.N., Deardorff, M.A., Klein, P.S., Cho,
K.W., Fraser, S.E., 2000. Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in
early embryogenesis. EMBO J 19, 1010–1022.
Rothe, M., Kanwal, N., Dietmann, P., Seigfried, F.A., Hempel, A.,
Schutz, D., Reim, D., Engels, R., Linnemann, A., Schmeisser,
M.J., Bockmann, J., Kuhl, M., Boeckers, T.M., Kuhl, S.J.,
2017. An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation. Development 144, 321–333.
Roy, J.P., Halford, M.M., Stacker, S.A., 2018. The biochemistry,
signalling and disease relevance of RYK and other WNTbinding receptor tyrosine kinases. Growth Factors 36, 15–40.
Salic, A., Lee, E., Mayer, L., Kirschner, M.W., 2000. Control of
beta-catenin stability: Reconstitution of the cytoplasmic
steps of the wnt pathway in Xenopus egg extracts. Mol Cell
5, 523–532.
Saneyoshi, T., Kume, S., Amasaki, Y., Mikoshiba, K., 2002. The
Wnt/calcium pathway activates NF-AT and promotes ventral
cell fate in Xenopus embryos. Nature 417, 295–299.
Saulnier, D.M., Ghanbari, H., Brandli, A.W., 2002. Essential function of Wnt-4 for tubulogenesis in the Xenopus pronephric
kidney. Dev Biol 248, 13–28.
Schambony, A., Wedlich, D., 2007. Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev Cell 12, 779–792.
Schneider, S., Steinbeisser, H., Warga, R.M., Hausen, P., 1996. Betacatenin translocation into nuclei demarcates the dorsalizing
centers in frog and fsh embryos. Mech Dev 57, 191–198.
Schneider, V.A., Mercola, M., 2001. Wnt antagonism initiates cardiogenesis in Xenopus laevis. Genes Dev 15, 304–315.
Schohl, A., Fagotto, F., 2003. A role for maternal beta-catenin
in early mesoderm induction in Xenopus. EMBO J 22,
3303–3313.
Seigfried, F.A., Cizelsky, W., Pfster, A.S., Dietmann, P., Walther, P.,
Kuhl, M., Kuhl, S.J., 2017. Frizzled 3 acts upstream of Alcam
during embryonic eye development. Dev Biol 426, 69–83.
Semenov, M., Tamai, K., He, X., 2005. SOST is a ligand for LRP5/
LRP6 and a Wnt signaling inhibitor. J Biol Chem 280,
26770–26775.
Sheldahl, L.C., Park, M., Malbon, C.C., Moon, R.T., 1999. Protein
kinase C is differentially stimulated by Wnt and Frizzled
homologs in a G-protein-dependent manner. Curr Biol 9,
695–698.
Shindo, A., Inoue, Y., Kinoshita, M., Wallingford, J.B., 2019. PCPdependent transcellular regulation of actomyosin oscillation
facilitates convergent extension of vertebrate tissue. Dev Biol
446, 159–167.
Slusarski, D.C., Yang-Snyder, J., Busa, W.B., Moon, R.T., 1997a.
Modulation of embryonic intracellular calcium signaling by
Wnt5A. Dev Biol 182, 114–120.
Slusarski, D.C., Corces, V.G., Moon, R.T., 1997b. Interaction of
Wnt and a Frizzled homologue triggers G-protein-linked
phosphatidylinositol signalling. Nature 390, 410–413.
Sokol, S.Y., 1996. Analysis of Dishevelled signalling pathways
during Xenopus development. Curr Biol 6, 1456–1467.
Strang, J.E., Schuler, R., Kuhl, M., Kestler, H.A., 2017. Switch-like
behavior enables Wnt11 concentration specifc response during dorso-ventral axis formation in Xenopus laevis. J Theor
Biol 429, 82–94.
Szenker-Ravi, E., Altunoglu, U., Leushacke, M., Bosso-Lefevre,
C., Khatoo, M., Thi Tran, H., Naert, T., Noelanders, R.,
Hajamohideen, A., Beneteau, C., de Sousa, S.B., Karaman, B.,
Latypova, X., Basaran, S., Yucel, E.B., Tan, T.T., Vlaminck,
L., Nayak, S.S., Shukla, A., Girisha, K.M., Le Caignec, C.,
Soshnikova, N., Uyguner, Z.O., Vleminckx, K., Barker, N.,
Kayserili, H., Reversade, B., 2018. RSPO2 inhibition of
RNF43 and ZNRF3 governs limb development independently
of LGR4/5/6. Nature 557, 564–569.
Tada, M., Smith, J.C., 2000. Xwnt11 is a target of Xenopus Brachyury:
Regulation of gastrulation movements via Dishevelled, but
not through the canonical Wnt pathway. Development 127,
2227–2238.
Takemaru, K.I., Moon, R.T., 2000. The transcriptional coactivator
CBP interacts with beta-catenin to activate gene expression.
J Cell Biol 149, 249–254.
Tamai, K., Semenov, M., Kato, Y., Spokony, R., Liu, C., Katsuyama, Y.,
Hess, F., Saint-Jeannet, J.P., He, X., 2000. LDL-receptor-related
proteins in Wnt signal transduction. Nature 407, 530–535.
Tanegashima, K., Zhao, H., Dawid, I.B., 2008. WGEF activates
Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation. EMBO J 27, 606–617.
Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D.,
Asashima, M., Wylie, C.C., Lin, X., Heasman, J., 2005.
Maternal wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos. Cell
120, 857–871.
Torres, M.A., Yang-Snyder, J.A., Purcell, S.M., DeMarais, A.A.,
McGrew, L.L., Moon, R.T., 1996. Activities of the Wnt-1
class of secreted signaling factors are antagonized by the
Wnt-5A class and by a dominant negative cadherin in early
Xenopus development. J Cell Biol 133, 1123–1137.
Van Nieuwenhuysen, T., Naert, T., Tran, H.T., Van Imschoot, G.,
Geurs, S., Sanders, E., Creytens, D., Van Roy, F., Vleminckx,
K., 2015. TALEN-mediated apc mutation in Xenopus
tropicalis phenocopies familial adenomatous polyposis.
Oncoscience 2, 555–566.
Veeman, M.T., Slusarski, D.C., Kaykas, A., Louie, S.H., Moon,
R.T., 2003. Zebrafsh prickle, a modulator of noncanonical
Wnt Signaling in Tissue Differentiation
Pandur, P., Lasche, M., Eisenberg, L.M., Kuhl, M., 2002. Wnt11 activation of a non-canonical Wnt signalling pathway is
required for cardiogenesis. Nature 418, 636–641.
Penzo-Mendez, A., Umbhauer, M., Djiane, A., Boucaut, J.C., Riou,
J.F., 2003. Activation of Gbetagamma signaling downstream
of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus
gastrulation. Dev Biol 257, 302–314.
Peters, J.M., McKay, R.M., McKay, J.P., Graff, J.M., 1999. Casein
kinase I transduces Wnt signals. Nature 401, 345–350.
Piccolo, S., Dupont, S., Cordenonsi, M., 2014. The biology of
YAP/TAZ: Hippo signaling and beyond. Physiol Rev 94,
1287–1312.
Podleschny, M., Grund, A., Berger, H., Rollwitz, E., Borchers, A.,
2015. A PTK7/Ror2 Co-receptor complex affects Xenopus
neural crest migration. PLoS One 10, e0145169.
Polevoy, H., Gutkovich, Y.E., Michaelov, A., Volovik, Y., Elkouby,
Y.M., Frank, D., 2019. New roles for Wnt and BMP signaling
in neural anteroposterior patterning. EMBO Rep 20.
Prieve, M.G., Moon, R.T., 2003. Stromelysin-1 and mesothelin
are differentially regulated by Wnt-5a and Wnt-1 in C57mg
mouse mammary epithelial cells. BMC Dev Biol 3, 2.
Ramakrishnan, A.-B., Sinha, A., Fan, V.B., Cadigan, K.M., 2018.
The Wnt transcriptional switch: TLE removal or inactivation? BioEssays 40.
Rasmussen, J.T., Deardorff, M.A., Tan, C., Rao, M.S., Klein, P.S.,
Vetter, M.L., 2001. Regulation of eye development by frizzled signaling in Xenopus. Proc Natl Acad Sci U S A 98,
3861–3866.
Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H.,
Moerer, P., van de Wetering, M., Destree, O., Clevers, H., 1998.
The Xenopus Wnt effector XTcf-3 interacts with Grouchorelated transcriptional repressors. Nature 395, 608–612.
Rothbacher, U., Laurent, M.N., Deardorff, M.A., Klein, P.S., Cho,
K.W., Fraser, S.E., 2000. Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in
early embryogenesis. EMBO J 19, 1010–1022.
Rothe, M., Kanwal, N., Dietmann, P., Seigfried, F.A., Hempel, A.,
Schutz, D., Reim, D., Engels, R., Linnemann, A., Schmeisser,
M.J., Bockmann, J., Kuhl, M., Boeckers, T.M., Kuhl, S.J.,
2017. An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation. Development 144, 321–333.
Roy, J.P., Halford, M.M., Stacker, S.A., 2018. The biochemistry,
signalling and disease relevance of RYK and other WNTbinding receptor tyrosine kinases. Growth Factors 36, 15–40.
Salic, A., Lee, E., Mayer, L., Kirschner, M.W., 2000. Control of
beta-catenin stability: Reconstitution of the cytoplasmic
steps of the wnt pathway in Xenopus egg extracts. Mol Cell
5, 523–532.
Saneyoshi, T., Kume, S., Amasaki, Y., Mikoshiba, K., 2002. The
Wnt/calcium pathway activates NF-AT and promotes ventral
cell fate in Xenopus embryos. Nature 417, 295–299.
Saulnier, D.M., Ghanbari, H., Brandli, A.W., 2002. Essential function of Wnt-4 for tubulogenesis in the Xenopus pronephric
kidney. Dev Biol 248, 13–28.
Schambony, A., Wedlich, D., 2007. Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev Cell 12, 779–792.
Schneider, S., Steinbeisser, H., Warga, R.M., Hausen, P., 1996. Betacatenin translocation into nuclei demarcates the dorsalizing
centers in frog and fsh embryos. Mech Dev 57, 191–198.
Schneider, V.A., Mercola, M., 2001. Wnt antagonism initiates cardiogenesis in Xenopus laevis. Genes Dev 15, 304–315.
Schohl, A., Fagotto, F., 2003. A role for maternal beta-catenin
in early mesoderm induction in Xenopus. EMBO J 22,
3303–3313.
Seigfried, F.A., Cizelsky, W., Pfster, A.S., Dietmann, P., Walther, P.,
Kuhl, M., Kuhl, S.J., 2017. Frizzled 3 acts upstream of Alcam
during embryonic eye development. Dev Biol 426, 69–83.
Semenov, M., Tamai, K., He, X., 2005. SOST is a ligand for LRP5/
LRP6 and a Wnt signaling inhibitor. J Biol Chem 280,
26770–26775.
Sheldahl, L.C., Park, M., Malbon, C.C., Moon, R.T., 1999. Protein
kinase C is differentially stimulated by Wnt and Frizzled
homologs in a G-protein-dependent manner. Curr Biol 9,
695–698.
Shindo, A., Inoue, Y., Kinoshita, M., Wallingford, J.B., 2019. PCPdependent transcellular regulation of actomyosin oscillation
facilitates convergent extension of vertebrate tissue. Dev Biol
446, 159–167.
Slusarski, D.C., Yang-Snyder, J., Busa, W.B., Moon, R.T., 1997a.
Modulation of embryonic intracellular calcium signaling by
Wnt5A. Dev Biol 182, 114–120.
Slusarski, D.C., Corces, V.G., Moon, R.T., 1997b. Interaction of
Wnt and a Frizzled homologue triggers G-protein-linked
phosphatidylinositol signalling. Nature 390, 410–413.
Sokol, S.Y., 1996. Analysis of Dishevelled signalling pathways
during Xenopus development. Curr Biol 6, 1456–1467.
Strang, J.E., Schuler, R., Kuhl, M., Kestler, H.A., 2017. Switch-like
behavior enables Wnt11 concentration specifc response during dorso-ventral axis formation in Xenopus laevis. J Theor
Biol 429, 82–94.
Szenker-Ravi, E., Altunoglu, U., Leushacke, M., Bosso-Lefevre,
C., Khatoo, M., Thi Tran, H., Naert, T., Noelanders, R.,
Hajamohideen, A., Beneteau, C., de Sousa, S.B., Karaman, B.,
Latypova, X., Basaran, S., Yucel, E.B., Tan, T.T., Vlaminck,
L., Nayak, S.S., Shukla, A., Girisha, K.M., Le Caignec, C.,
Soshnikova, N., Uyguner, Z.O., Vleminckx, K., Barker, N.,
Kayserili, H., Reversade, B., 2018. RSPO2 inhibition of
RNF43 and ZNRF3 governs limb development independently
of LGR4/5/6. Nature 557, 564–569.
Tada, M., Smith, J.C., 2000. Xwnt11 is a target of Xenopus Brachyury:
Regulation of gastrulation movements via Dishevelled, but
not through the canonical Wnt pathway. Development 127,
2227–2238.
Takemaru, K.I., Moon, R.T., 2000. The transcriptional coactivator
CBP interacts with beta-catenin to activate gene expression.
J Cell Biol 149, 249–254.
Tamai, K., Semenov, M., Kato, Y., Spokony, R., Liu, C., Katsuyama, Y.,
Hess, F., Saint-Jeannet, J.P., He, X., 2000. LDL-receptor-related
proteins in Wnt signal transduction. Nature 407, 530–535.
Tanegashima, K., Zhao, H., Dawid, I.B., 2008. WGEF activates
Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation. EMBO J 27, 606–617.
Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D.,
Asashima, M., Wylie, C.C., Lin, X., Heasman, J., 2005.
Maternal wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos. Cell
120, 857–871.
Torres, M.A., Yang-Snyder, J.A., Purcell, S.M., DeMarais, A.A.,
McGrew, L.L., Moon, R.T., 1996. Activities of the Wnt-1
class of secreted signaling factors are antagonized by the
Wnt-5A class and by a dominant negative cadherin in early
Xenopus development. J Cell Biol 133, 1123–1137.
Van Nieuwenhuysen, T., Naert, T., Tran, H.T., Van Imschoot, G.,
Geurs, S., Sanders, E., Creytens, D., Van Roy, F., Vleminckx,
K., 2015. TALEN-mediated apc mutation in Xenopus
tropicalis phenocopies familial adenomatous polyposis.
Oncoscience 2, 555–566.
Veeman, M.T., Slusarski, D.C., Kaykas, A., Louie, S.H., Moon,
R.T., 2003. Zebrafsh prickle, a modulator of noncanonical