123
Notch Signaling in Early Embryogenesis
Genome evolution in the allotetraploid frog Xenopus laevis.
Nature 538, 336–343. https://doi.org/10.1038/nature19840
Shinga, J., Itoh, M., Shiokawa, K., Taira, S., Taira, M., 2001.
Early patterning of the prospective midbrain: Hindbrain
boundary by the HES-related gene XHR1 in Xenopus
embryos. Mech. Dev. 109, 225–239. https://doi.org/10.1016/
S0925-4773(01)00528-7
Shook, D.R., Majer, C., Keller, R., 2004. Pattern and morphogenesis
of presumptive superfcial mesoderm in two closely related
species, Xenopus laevis and Xenopus tropicalis. Dev. Biol.
270, 163–185. https://doi.org/10.1016/j.ydbio.2004.02.021
Sjöqvist, M., Andersson, E.R., 2019. Do as I say, Not(ch) as I do:
Lateral control of cell fate. Dev. Biol. 447, 58–70. https://doi.
org/10.1016/j.ydbio.2017.09.032
Sölter, M., Locker, M., Boy, S., Taelman, V., Bellefroid, E.J.,
Perron, M., Pieler, T., 2006. Characterization and function
of the bHLH-O protein XHes2: Insight into the mechanisms
controlling retinal cell fate decision. Development 133,
4097–4108. https://doi.org/10.1242/dev.02567
Souopgui, J., Sölter, M., Pieler, T., 2002. XPak3 promotes cell
cycle withdrawal during primary neurogenesis in Xenopus
laevis. EMBO J. 21, 6429–6439.
Sparrow, D.B., 2008. Old wares and new: Five decades of investigation of somitogenesis in Xenopus laevis. Adv. Exp. Med. Biol.
638, 73–94. https://doi.org/10.1007/978-0-387-09606-3_4
Sparrow, D.B., Jen, W.C., Kotecha, S., Towers, N., Kintner, C.,
Mohun, T.J., 1998. Thylacine 1 is expressed segmentally
within the paraxial mesoderm of the Xenopus embryo
and interacts with the Notch pathway. Development 125,
2041–2051.
Steventon, B., Mayor, R., 2012. Early neural crest induction
requires an initial inhibition of Wnt signals. Dev Biol 365,
196–207. https://doi.org/10.1016/j.ydbio.2012.02.029
Steventon, B., Mayor, R., Streit, A., 2014. Neural crest and placode interaction during the development of the cranial sensory system. Dev. Biol. 389, 28–38. https://doi.org/10.1016/j.
ydbio.2014.01.021
Stuhlmiller, T.J., García-Castro, M.I., 2012. Current perspectives
of the signaling pathways directing neural crest induction.
Cell. Mol. Life Sci. 69, 3715–3737. https://doi.org/10.1007/
s00018-012-0991-8
Taelman, V., Van Campenhout, C., Sölter, M., Pieler, T., Bellefroid,
E.J., 2006. The Notch-effector HRT1 gene plays a role in
glomerular development and patterning of the Xenopus pronephros anlagen. Development 133, 2961–2971. https://doi.
org/10.1242/dev.02458
Taelman, V., Van Wayenbergh, R., Sölter, M., Pichon, B., Pieler,
T., Christophe, D., Bellefroid, E.J., 2004. Sequences
downstream of the bHLH domain of the Xenopus hairyrelated transcription factor-1 act as an extended dimerization domain that contributes to the selection of the
partners. Dev. Biol. 276, 47–63. https://doi.org/10.1016/j.
ydbio.2004.08.019
Takada, H., Hattori, D., Kitayama, A., Ueno, N., Taira, M., 2005.
Identifcation of target genes for the Xenopus Hes-related
protein XHR1, a prepattern factor specifying the midbrainhindbrain boundary. Dev. Biol. 283, 253–267. https://doi.
org/10.1016/j.ydbio.2005.04.020
Takahashi, Y., Koizumi, K.I., Takagi, A., Kitajima, S., Inoue, T.,
Koseki, H., Saga, Y., 2000. Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat. Genet. 25,
390–396. https://doi.org/10.1038/78062
Tanigaki, K., Honjo, T., 2010. Two opposing roles of RBP-J in
Notch signaling. Curr. Top. Dev. Biol. 92, 231–252. https://
doi.org/10.1016/S0070-2153(10)92007-3
Taverner, N. V., Kofron, M., Shin, Y., Kabitschke, C., Gilchrist,
M.J., Wylie, C., Cho, K.W.Y., Heasman, J., Smith, J.C., 2005.
Microarray-based identif cation of VegT targets in Xenopus.
Mech. Dev. 122, 333–354. https://doi.org/10.1016/J.MOD.
2004.10.010
Thisse, B., Thisse, C., 2015. Formation of the vertebrate embryo:
Moving beyond the Spemann organizer. Semin. Cell Dev.
Biol. 42, 1–9. https://doi.org/10.1016/j.semcdb.2015.05.
007
Thurmond, J., Goodman, J.L., Strelets, V.B., Attrill, H., Gramates,
L.S., Marygold, S.J., Matthews, B.B., Millburn, G.,
Antonazzo, G., Trovisco, V., Kaufman, T.C., Calvi, B.R.,
Perrimon, N., Gelbart, S.R., Agapite, J., Broll, K., Crosby,
L., Dos Santos, G., Emmert, D., Falls, K., Jenkins, V.,
Sutherland, C., Tabone, C., Zhou, P., Zytkovicz, M., Brown,
N., Garapati, P., Holmes, A., Larkin, A., Pilgrim, C., Urbano,
P., Czoch, B., Cripps, R., Baker, P., 2019. FlyBase 2.0: The
next generation. Nucleic Acids Res. 47, D759–D765. https://
doi.org/10.1093/nar/gky1003
Tomankova, S., Abaffy, P., Sindelka, R., 2017. The role of nitric
oxide during embryonic epidermis development of Xenopus
laevis. Biol. Open 6, 862–871. https://doi.org/10.1242/bio.
023739
Tözser, J., Earwood, R., Kato, A., Brown, J., Tanaka, K., Didier,
R., Megraw, T.L., Blum, M., Kato, Y., 2015. TGF-β signaling regulates the differentiation of motile cilia. Cell Rep. 11,
1000–1007. https://doi.org/10.1016/j.celrep.2015.04.025
Tsuji, S., Cho, K.W.Y., Hashimoto, C., 2003. Expression pattern
of a basic helix-loop-helix transcription factor Xhairy2b
during Xenopus laevis development. Dev. Genes Evol. 213,
407–411. https://doi.org/10.1007/s00427-003-0338-4
Turner, D.L., Weintraub, H., 1994. Expression of achaete-scute
homolog 3 in Xenopus embryos converts ectodermal cells
to a neural fate. Genes Dev. 8, 1434–1447. https://doi.
org/10.1101/gad.8.12.1434
Ueno, T., Ishihara, A., Yagi, S., Koike, T., Yamauchi, K., Shiojiri,
N., 2015. Histochemical analyses of biliary development
during metamorphosis of Xenopus laevis tadpoles. Zool. Sci.
32, 88–96. https://doi.org/10.2108/zs140104
Umbhauer, M., Boucaut, J.C., Shi, D.L., 2001. Repression of
XMyoD expression and myogenesis by Xhairy-1 in Xenopus
early embryo. Mech. Dev. 109, 61–68.
Vasiliu, D., Clamons, S., McDonough, M., Rabe, B., Saha, M.,
2015. A regression-based differential expression detection algorithm for microarray studies with ultra-low sample size. PLoS One 10. https://doi.org/10.1371/journal.
pone.0118198
Vega-López, G.A., Bonano, M., Tríbulo, C., Fernández, J.P.,
Agüero, T.H., Aybar, M.J., 2015. Functional analysis of
Hairy genes in Xenopus neural crest initial specif cation
and cell migration. Dev. Dyn. 244, 988–1013. https://doi.
org/10.1002/dvdy.24295
Venzin, O.F., Oates, A.C., 2020. What are you synching about?
Emerging complexity of Notch signaling in the segmentation clock. Dev. Biol. 460, 40–54. https://doi.org/10.1016/j.
ydbio.2019.06.024
Vernon, A.E., Movassagh, M., Horan, I., Wise, H., Ohnuma, S.,
Philpott, A., 2006. Notch targets the Cdk inhibitor Xic1
to regulate differentiation but not the cell cycle in neurons. EMBO Rep. 7, 643–648. https://doi.org/10.1038/
sj.embor.7400691
Wacker, S.A., Alvarado, C., von Wichert, G., Knippschild, U.,
Wiedenmann, J., Clauss, K., Nienhaus, G.U., Hameister,
H., Baumann, B., Borggrefe, T., Knöchel, W., Oswald, F.,
2011. RITA, a novel modulator of Notch signalling, acts via
Notch Signaling in Early Embryogenesis
Genome evolution in the allotetraploid frog Xenopus laevis.
Nature 538, 336–343. https://doi.org/10.1038/nature19840
Shinga, J., Itoh, M., Shiokawa, K., Taira, S., Taira, M., 2001.
Early patterning of the prospective midbrain: Hindbrain
boundary by the HES-related gene XHR1 in Xenopus
embryos. Mech. Dev. 109, 225–239. https://doi.org/10.1016/
S0925-4773(01)00528-7
Shook, D.R., Majer, C., Keller, R., 2004. Pattern and morphogenesis
of presumptive superfcial mesoderm in two closely related
species, Xenopus laevis and Xenopus tropicalis. Dev. Biol.
270, 163–185. https://doi.org/10.1016/j.ydbio.2004.02.021
Sjöqvist, M., Andersson, E.R., 2019. Do as I say, Not(ch) as I do:
Lateral control of cell fate. Dev. Biol. 447, 58–70. https://doi.
org/10.1016/j.ydbio.2017.09.032
Sölter, M., Locker, M., Boy, S., Taelman, V., Bellefroid, E.J.,
Perron, M., Pieler, T., 2006. Characterization and function
of the bHLH-O protein XHes2: Insight into the mechanisms
controlling retinal cell fate decision. Development 133,
4097–4108. https://doi.org/10.1242/dev.02567
Souopgui, J., Sölter, M., Pieler, T., 2002. XPak3 promotes cell
cycle withdrawal during primary neurogenesis in Xenopus
laevis. EMBO J. 21, 6429–6439.
Sparrow, D.B., 2008. Old wares and new: Five decades of investigation of somitogenesis in Xenopus laevis. Adv. Exp. Med. Biol.
638, 73–94. https://doi.org/10.1007/978-0-387-09606-3_4
Sparrow, D.B., Jen, W.C., Kotecha, S., Towers, N., Kintner, C.,
Mohun, T.J., 1998. Thylacine 1 is expressed segmentally
within the paraxial mesoderm of the Xenopus embryo
and interacts with the Notch pathway. Development 125,
2041–2051.
Steventon, B., Mayor, R., 2012. Early neural crest induction
requires an initial inhibition of Wnt signals. Dev Biol 365,
196–207. https://doi.org/10.1016/j.ydbio.2012.02.029
Steventon, B., Mayor, R., Streit, A., 2014. Neural crest and placode interaction during the development of the cranial sensory system. Dev. Biol. 389, 28–38. https://doi.org/10.1016/j.
ydbio.2014.01.021
Stuhlmiller, T.J., García-Castro, M.I., 2012. Current perspectives
of the signaling pathways directing neural crest induction.
Cell. Mol. Life Sci. 69, 3715–3737. https://doi.org/10.1007/
s00018-012-0991-8
Taelman, V., Van Campenhout, C., Sölter, M., Pieler, T., Bellefroid,
E.J., 2006. The Notch-effector HRT1 gene plays a role in
glomerular development and patterning of the Xenopus pronephros anlagen. Development 133, 2961–2971. https://doi.
org/10.1242/dev.02458
Taelman, V., Van Wayenbergh, R., Sölter, M., Pichon, B., Pieler,
T., Christophe, D., Bellefroid, E.J., 2004. Sequences
downstream of the bHLH domain of the Xenopus hairyrelated transcription factor-1 act as an extended dimerization domain that contributes to the selection of the
partners. Dev. Biol. 276, 47–63. https://doi.org/10.1016/j.
ydbio.2004.08.019
Takada, H., Hattori, D., Kitayama, A., Ueno, N., Taira, M., 2005.
Identifcation of target genes for the Xenopus Hes-related
protein XHR1, a prepattern factor specifying the midbrainhindbrain boundary. Dev. Biol. 283, 253–267. https://doi.
org/10.1016/j.ydbio.2005.04.020
Takahashi, Y., Koizumi, K.I., Takagi, A., Kitajima, S., Inoue, T.,
Koseki, H., Saga, Y., 2000. Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat. Genet. 25,
390–396. https://doi.org/10.1038/78062
Tanigaki, K., Honjo, T., 2010. Two opposing roles of RBP-J in
Notch signaling. Curr. Top. Dev. Biol. 92, 231–252. https://
doi.org/10.1016/S0070-2153(10)92007-3
Taverner, N. V., Kofron, M., Shin, Y., Kabitschke, C., Gilchrist,
M.J., Wylie, C., Cho, K.W.Y., Heasman, J., Smith, J.C., 2005.
Microarray-based identif cation of VegT targets in Xenopus.
Mech. Dev. 122, 333–354. https://doi.org/10.1016/J.MOD.
2004.10.010
Thisse, B., Thisse, C., 2015. Formation of the vertebrate embryo:
Moving beyond the Spemann organizer. Semin. Cell Dev.
Biol. 42, 1–9. https://doi.org/10.1016/j.semcdb.2015.05.
007
Thurmond, J., Goodman, J.L., Strelets, V.B., Attrill, H., Gramates,
L.S., Marygold, S.J., Matthews, B.B., Millburn, G.,
Antonazzo, G., Trovisco, V., Kaufman, T.C., Calvi, B.R.,
Perrimon, N., Gelbart, S.R., Agapite, J., Broll, K., Crosby,
L., Dos Santos, G., Emmert, D., Falls, K., Jenkins, V.,
Sutherland, C., Tabone, C., Zhou, P., Zytkovicz, M., Brown,
N., Garapati, P., Holmes, A., Larkin, A., Pilgrim, C., Urbano,
P., Czoch, B., Cripps, R., Baker, P., 2019. FlyBase 2.0: The
next generation. Nucleic Acids Res. 47, D759–D765. https://
doi.org/10.1093/nar/gky1003
Tomankova, S., Abaffy, P., Sindelka, R., 2017. The role of nitric
oxide during embryonic epidermis development of Xenopus
laevis. Biol. Open 6, 862–871. https://doi.org/10.1242/bio.
023739
Tözser, J., Earwood, R., Kato, A., Brown, J., Tanaka, K., Didier,
R., Megraw, T.L., Blum, M., Kato, Y., 2015. TGF-β signaling regulates the differentiation of motile cilia. Cell Rep. 11,
1000–1007. https://doi.org/10.1016/j.celrep.2015.04.025
Tsuji, S., Cho, K.W.Y., Hashimoto, C., 2003. Expression pattern
of a basic helix-loop-helix transcription factor Xhairy2b
during Xenopus laevis development. Dev. Genes Evol. 213,
407–411. https://doi.org/10.1007/s00427-003-0338-4
Turner, D.L., Weintraub, H., 1994. Expression of achaete-scute
homolog 3 in Xenopus embryos converts ectodermal cells
to a neural fate. Genes Dev. 8, 1434–1447. https://doi.
org/10.1101/gad.8.12.1434
Ueno, T., Ishihara, A., Yagi, S., Koike, T., Yamauchi, K., Shiojiri,
N., 2015. Histochemical analyses of biliary development
during metamorphosis of Xenopus laevis tadpoles. Zool. Sci.
32, 88–96. https://doi.org/10.2108/zs140104
Umbhauer, M., Boucaut, J.C., Shi, D.L., 2001. Repression of
XMyoD expression and myogenesis by Xhairy-1 in Xenopus
early embryo. Mech. Dev. 109, 61–68.
Vasiliu, D., Clamons, S., McDonough, M., Rabe, B., Saha, M.,
2015. A regression-based differential expression detection algorithm for microarray studies with ultra-low sample size. PLoS One 10. https://doi.org/10.1371/journal.
pone.0118198
Vega-López, G.A., Bonano, M., Tríbulo, C., Fernández, J.P.,
Agüero, T.H., Aybar, M.J., 2015. Functional analysis of
Hairy genes in Xenopus neural crest initial specif cation
and cell migration. Dev. Dyn. 244, 988–1013. https://doi.
org/10.1002/dvdy.24295
Venzin, O.F., Oates, A.C., 2020. What are you synching about?
Emerging complexity of Notch signaling in the segmentation clock. Dev. Biol. 460, 40–54. https://doi.org/10.1016/j.
ydbio.2019.06.024
Vernon, A.E., Movassagh, M., Horan, I., Wise, H., Ohnuma, S.,
Philpott, A., 2006. Notch targets the Cdk inhibitor Xic1
to regulate differentiation but not the cell cycle in neurons. EMBO Rep. 7, 643–648. https://doi.org/10.1038/
sj.embor.7400691
Wacker, S.A., Alvarado, C., von Wichert, G., Knippschild, U.,
Wiedenmann, J., Clauss, K., Nienhaus, G.U., Hameister,
H., Baumann, B., Borggrefe, T., Knöchel, W., Oswald, F.,
2011. RITA, a novel modulator of Notch signalling, acts via