101
jag1
dlc
Expression in the pair of medial stripes of PN ( Peres and
dlc MO: ↓primary neurons (ISH tubb2b, NF21) without affecting
Durston, 2006 ).
neurog2 in the medial stripe (ISH, NF21) ( Peres and Durston,
In the neural plate, dlc is necessary for terminal neuronal
2006 ).
differentiation in the medial stripe of PN.
Expressed in the ANB, in a pair of transversal, bilateral
stripes corresponding to the future mesencephalon,
trigeminal placodes, and two pairs of bilateral AP stripes
in the posterior neural plate, one presumably
corresponding to the developing intermediate neurons
and the other in-between the medial and intermediate
dll1 stripes ( Kiyota et al., 2001 ).
jag1 inhibits PN. This does not rely on dll1
down-regulation.
jag1 overexpression : ↓PN without affecting dll1 ; prevented
the increase of PN induced by dll1 STU ( Kiyota et al.,
2001 ).
jag1ICD: translocated to the nucleus, ↓PN ( Kiyota and
Kinoshita, 2004 ).
See hes5.1 in Table 7.3 .
DN-jag1 (lacking the intracellular domain): ↑PN; this was
rescued by dll1 in a dose-dependent manner ( Kiyota et al.,
2001 ).
Notch Signaling in Early Embryogenesis