Réponses au niveau cellulaire et conséquences
273
Si beaucoup des mécanismes impliqués sont très documentés, les connaissances sur certains autres restent parcellaires, souvent dues à leur récente mise en
évidence. L’organisation et la coordination de la réponse cellulaire restent encore
à documenter compte tenu de la variété des stress possibles. Enfin les mécanismes
moléculaires sous-jacents à certaines réponses cellulaires (effets non ciblés, sénescence) restent à caractériser précisément.
Références bibliographiques
Baptista MS, Vasconcelos MT (2006). Cyanobacteria metal interactions, requierements,
toxicity, and ecological implications. Crit
Rev Microbiology, 32 : 127-137.
Bertrand P, Saintigny Y, Lopez BS (2004).
p53’s double life: transactivation-independent repression of homologous recombination. Trends Genet, 20 : 235-243.
Blank M, Shiloh Y (2007). Programs for cell
death: apoptosis is only one way to go. Cell
Cycle, 6 : 686-695.
Bravard A, Luccioni C, Moustacchi E and
Rigaud O (1999). Contribution of antioxidant enzymes to the response of human
lymphoblasts. Int J Radiat Biol, 75 : 639645.
Courtois-Cox S, Jones SL, Cichowski K
(2008). Many roads lead to oncogene-induced senescence. Oncogene, 27 : 2801-2809.
Lavin MF (2007). ATM and the Mrell complex combine to recognize and signal DNA
double-strand breaks. Oncogene, 26 : 77497758.
Le XC, Xing JZ, Lee J, Leadon SA and Wein§
feld M (1998). Inducible repair of thymine
=
glycol detected by an ultrasensitive assay
“
for DNA damage. Science, 280 : 1066-1069.
■o
| Lee JH, Paull TT (2007). Activation and regu«
lation of ATM kinase activity in response
g
to DNA double-strand breaks. Oncogene,
|
26 : 7741-7748.
0 0
.
à Little JB (2003). Genomic instability and
s
bystander effects: a historical perspective.
I
Oncogene, 22 : 6978-6987.
5 Lloyd JR, Lovley DR (2001). Microbial
’
detoxification of metals and radionuclides.
Curr Opin Biotechnol, 12 : 248-253.
Lorimore SA, Coates PJ, Wright EG (2003).
Radiation-induced genomic instability and
bystander effects: inter-related nontargeted
effects of exposure to ionizing radiation.
Oncogene, 22 : 7058-7069.
Mallette FA, Ferbeyre G (2007). The DNA
damage signaling pathway connects oncogenic stress to cellular senescence. Cell
Cycle, 6 : 1831-1836.
Matsumoto H, Hamada N, Takahashi A,
Kobayashi Y, Ohnishi T (2007b). Vanguards
of paradigm shift in radiation biology:
radiation-induced adaptive and bystander
responses. J Radiat Res, 48 : 97-106.
Mothersill C, Seymour C (2003). Radiationinduced bystander effects, carcinogenesis
and models. Oncogene, 22 : 7028-7033.
Olivieri G, Bodycote J, Wolff S (1984). Adaptive response of human lymphocytes to the
low concentrations of radioactive thymidine. Science, 223 : 594-597.
Prieur A, Peeper DS (2008). Cellular senescence in vivo: a barrier to tumorigenesis.
Curr Opin Cell Biol, 20 : 150-155.
Rigaud O (1998). La radioadaptation : aspects
cellulaires et moléculaires d'une réponse
aux faibles doses de radiations ionisantes.
Radioprotection, 33 : 389-404.
De Toledo SM, Asaad N, Venkatachalam P, Li
L, Howell RW, Spitz DR, Azzam El (2006).
Adaptive responses to low-dose/low-doserate gamma rays in normal human fibroblasts: the role of growth architecture and
oxidative metabolism. Radiat Res, 166 :
849-857.
Tran D. Bourdineaud JP, Massabuau JC,
Garnier-Laplace J (2005). Modulation of
bioaccumulation by hypoxia in the fres-
273
Si beaucoup des mécanismes impliqués sont très documentés, les connaissances sur certains autres restent parcellaires, souvent dues à leur récente mise en
évidence. L’organisation et la coordination de la réponse cellulaire restent encore
à documenter compte tenu de la variété des stress possibles. Enfin les mécanismes
moléculaires sous-jacents à certaines réponses cellulaires (effets non ciblés, sénescence) restent à caractériser précisément.
Références bibliographiques
Baptista MS, Vasconcelos MT (2006). Cyanobacteria metal interactions, requierements,
toxicity, and ecological implications. Crit
Rev Microbiology, 32 : 127-137.
Bertrand P, Saintigny Y, Lopez BS (2004).
p53’s double life: transactivation-independent repression of homologous recombination. Trends Genet, 20 : 235-243.
Blank M, Shiloh Y (2007). Programs for cell
death: apoptosis is only one way to go. Cell
Cycle, 6 : 686-695.
Bravard A, Luccioni C, Moustacchi E and
Rigaud O (1999). Contribution of antioxidant enzymes to the response of human
lymphoblasts. Int J Radiat Biol, 75 : 639645.
Courtois-Cox S, Jones SL, Cichowski K
(2008). Many roads lead to oncogene-induced senescence. Oncogene, 27 : 2801-2809.
Lavin MF (2007). ATM and the Mrell complex combine to recognize and signal DNA
double-strand breaks. Oncogene, 26 : 77497758.
Le XC, Xing JZ, Lee J, Leadon SA and Wein§
feld M (1998). Inducible repair of thymine
=
glycol detected by an ultrasensitive assay
“
for DNA damage. Science, 280 : 1066-1069.
■o
| Lee JH, Paull TT (2007). Activation and regu«
lation of ATM kinase activity in response
g
to DNA double-strand breaks. Oncogene,
|
26 : 7741-7748.
0 0
.
à Little JB (2003). Genomic instability and
s
bystander effects: a historical perspective.
I
Oncogene, 22 : 6978-6987.
5 Lloyd JR, Lovley DR (2001). Microbial
’
detoxification of metals and radionuclides.
Curr Opin Biotechnol, 12 : 248-253.
Lorimore SA, Coates PJ, Wright EG (2003).
Radiation-induced genomic instability and
bystander effects: inter-related nontargeted
effects of exposure to ionizing radiation.
Oncogene, 22 : 7058-7069.
Mallette FA, Ferbeyre G (2007). The DNA
damage signaling pathway connects oncogenic stress to cellular senescence. Cell
Cycle, 6 : 1831-1836.
Matsumoto H, Hamada N, Takahashi A,
Kobayashi Y, Ohnishi T (2007b). Vanguards
of paradigm shift in radiation biology:
radiation-induced adaptive and bystander
responses. J Radiat Res, 48 : 97-106.
Mothersill C, Seymour C (2003). Radiationinduced bystander effects, carcinogenesis
and models. Oncogene, 22 : 7028-7033.
Olivieri G, Bodycote J, Wolff S (1984). Adaptive response of human lymphocytes to the
low concentrations of radioactive thymidine. Science, 223 : 594-597.
Prieur A, Peeper DS (2008). Cellular senescence in vivo: a barrier to tumorigenesis.
Curr Opin Cell Biol, 20 : 150-155.
Rigaud O (1998). La radioadaptation : aspects
cellulaires et moléculaires d'une réponse
aux faibles doses de radiations ionisantes.
Radioprotection, 33 : 389-404.
De Toledo SM, Asaad N, Venkatachalam P, Li
L, Howell RW, Spitz DR, Azzam El (2006).
Adaptive responses to low-dose/low-doserate gamma rays in normal human fibroblasts: the role of growth architecture and
oxidative metabolism. Radiat Res, 166 :
849-857.
Tran D. Bourdineaud JP, Massabuau JC,
Garnier-Laplace J (2005). Modulation of
bioaccumulation by hypoxia in the fres-