Marine lipids
which involve acylation, oxidation and retroconversion. Hence they
support that the lower content of 22:6 (n-3) in the blood and brain of
formula-fed infants is not due to a difference in the β-oxidation rates
between 18:3 (n-3) and 22:6 (n-3).
Further studies using the tracer method and isolated organites (peroxisomes
and mitochondria) should bring more information about the β-oxidation
of these two (n-3) fatty acids.
Acknowtedgments
The authors are grateful to Patrice Dahirel for animal care and to Annick Bouroche
for revising the manuscript (service linguistique, unité centrale de documention).
Bibliographic references
Birch E.E., Birch D.G., Hoftman D., Uauy R., 1992. Dietary essential
fatty acid supply and visual acuity development. Invest. Ophthalmol. Visual Sci., 33, 3242-3253.
Brossard N., Croset M., Pachiaudi C., Riou J.P., Tayot J.L., Lagarde
M., 1996. Retroconversion and metabolism of [
13 C]22 :6 (n-3) in
humans and rats after a single dose of [
13 C]22 :6 (n-3) triacylglycerols. Amer. J. Clin. Nutr., 64, 5
7 7-586.
Connor W., Neuringer M., Reisbick S., 1992. Essential fatty acids.
The importance ol (n-3) fatty acicls in the retina and brain. Nutr.
Rev., 50, 21-29.
Cunnane S.C., Anderson M.J., 1997. The majority of dietary linolenate
in growing rats is β-oxidized orstored in visceral fat. J. Nutr., 127,
146-152.
ESPGAN Committee on Nutrition, 1991. Comment on the contents and
composition of lipids in infants formulas. Acta Pediat. Scan., 80,
887-896.
Folch J., Lees M., Sloane-Stanley G., 1957. A simple method for the
isolation and purification ol total lipids from animal tissue. J. Biol.
Chem., 226, 497-506.
Guesnet R, Alasnier C., Alessandri J.M., Durand G., 1997. (n-3) Polyunsaturated fatty acid requirement of pregnant female and suckling
pup in the rat. Lipids, 32, 527-34.
Innis S.M., 1991. Essential fatty acids in growth and development.
Prog. Lipid Res., 30, 39-103.
Lemberger T, Desvergne B., Wahli W., 1996. Peroxisome proliferatoractivated receptor: a nuclear signaling pathway in lipid physiology.
Annu. Rev. Cell Dev. Biol., 12, 335-363.
162
which involve acylation, oxidation and retroconversion. Hence they
support that the lower content of 22:6 (n-3) in the blood and brain of
formula-fed infants is not due to a difference in the β-oxidation rates
between 18:3 (n-3) and 22:6 (n-3).
Further studies using the tracer method and isolated organites (peroxisomes
and mitochondria) should bring more information about the β-oxidation
of these two (n-3) fatty acids.
Acknowtedgments
The authors are grateful to Patrice Dahirel for animal care and to Annick Bouroche
for revising the manuscript (service linguistique, unité centrale de documention).
Bibliographic references
Birch E.E., Birch D.G., Hoftman D., Uauy R., 1992. Dietary essential
fatty acid supply and visual acuity development. Invest. Ophthalmol. Visual Sci., 33, 3242-3253.
Brossard N., Croset M., Pachiaudi C., Riou J.P., Tayot J.L., Lagarde
M., 1996. Retroconversion and metabolism of [
13 C]22 :6 (n-3) in
humans and rats after a single dose of [
13 C]22 :6 (n-3) triacylglycerols. Amer. J. Clin. Nutr., 64, 5
7 7-586.
Connor W., Neuringer M., Reisbick S., 1992. Essential fatty acids.
The importance ol (n-3) fatty acicls in the retina and brain. Nutr.
Rev., 50, 21-29.
Cunnane S.C., Anderson M.J., 1997. The majority of dietary linolenate
in growing rats is β-oxidized orstored in visceral fat. J. Nutr., 127,
146-152.
ESPGAN Committee on Nutrition, 1991. Comment on the contents and
composition of lipids in infants formulas. Acta Pediat. Scan., 80,
887-896.
Folch J., Lees M., Sloane-Stanley G., 1957. A simple method for the
isolation and purification ol total lipids from animal tissue. J. Biol.
Chem., 226, 497-506.
Guesnet R, Alasnier C., Alessandri J.M., Durand G., 1997. (n-3) Polyunsaturated fatty acid requirement of pregnant female and suckling
pup in the rat. Lipids, 32, 527-34.
Innis S.M., 1991. Essential fatty acids in growth and development.
Prog. Lipid Res., 30, 39-103.
Lemberger T, Desvergne B., Wahli W., 1996. Peroxisome proliferatoractivated receptor: a nuclear signaling pathway in lipid physiology.
Annu. Rev. Cell Dev. Biol., 12, 335-363.
162