5. ANTIBIOSIS AND ANTIBIOTICS
285
TABLE III (Continued)
Degradation products
streptomycetes: albomycin (166a,b), ferrimycin (167a-168) }
grisein A,
which, together with other less well known iron-containing antibiotics,
have been grouped under the collective name sideromycins (169). They
are believed to act as specific inhibitors of iron-containing growth factors
(170a) constituting the group of sideramines (170b, 171, 172a). The
compound l-amino-5-hydroxylaminopentane occurs in acid hydrolyzates
of several sideramines and sideromycins (172b) as well as in the antibiotic nocardamine (XLII) (172c) which, iron-complexed, is identical
with ferrioxamine Ε (163a). The related l-amino-5-hydroxylaminopentan1-oic acid is a component of mycobactin, a growth factor for Mycobacterium johnei biosynthesized by M. phlei (172d). Table III also indiTryptophan
Tyrosine
/S-Methylphenylalanine
Phenylalanine
/3-Lysine
Arginine
l-Amino-5-hydroxyaminopentane
Cadaverine
Ornithine
a,7-Diaminobutyric acid
a,j8-Diaminobutyric acid
α,/3-Diaminopropionic acid
Glutamic acid
ß-Methylaspartic acid
Aspartic acid
Isoleucine
j8-Hydroxyleucine
Leucine
δ-Aminovaleric acid
Valine
Threonine
a-Aminoisobutyric"acid
Cysteic acid
Cysteine
Serino
j8-Alanine
Alanine
Ethanolamine
Glycine
Hydroxylamine