236
G. L. CANTONI
VI. Conclusions
Although much remains to be learned, it is becoming evident that
onium compounds are an important group of naturally occurring compounds. The considerable range of their biological distribution, the
chemical and enzymatic reactivity conferred by the presence of the
onium pole, and the important physiological and pharmacological
effects elicited by some of these compounds all point to the need for
further explorations in the chemistry, biochemistry, and biology of these
interesting compounds.
ACKNOWLEDGMENTS
The author takes great pleasure in acknowledging the helpful discussions and
suggestions of Drs. S. H. Mudd, W. A. Klee, J. Durell, and a number of other
collaborators and colleagues at the National Institutes of Health, and in particular
he is grateful to Dr. G. A. Jamieson for discussion and advice on the more chemical
aspects of this review. Thankful acknowledgment is due to Journal of Biological
Chemistry, Biochemical Journal and Biochim. et Biophys. Acta for permission
to reproduce figures and tables as indicated.
References
1. G. W. Wheeland, "Advanced Organic Chemistry," 2nd ed. Wiley, New
York, 1953.
2. G. M. Bennet and A. W. Chapman. Ann. Repts. on Progr. Chem. (Chem.
Soc, London) p. 143 (1931).
3. P. B. D. de la Mare, Ann. Repts. on Progr. Chem. (Chem. Soc, London)
p. 134 (1950).
4. M. L. Dhar, E. D. Hughes, C. R. Ingold, K. M. M. Mandour, G. A. Maw,
and L. I. Woolf, /. Chem. Soc. p. 2093 (1948).
5. R. Willstätter, Ber. deut. ehem. Ges. 35, 584 (1902).
6. T. S. Stevens, E. M. Creighton, A. B. Gordon, and M. MacNicol, /. Chem.
Soc. p. 3193 (1928).
7. T. Thompson and T. S. Stevens, /. Chem. Soc. p. 69 (1932).
8. C. R. Hansen and S. W. Kantor, /. Am. Chem. Soc. 73, 4122 (1951).
9. A. J. Birch, R. J. English, R. A. Massy-Westoff, M. Slaytor, and H. Smith,
/. Chem. Soc. p. 365 (1958).
10. M. Guggenheim, "Die Biogenen Amine." Karger, Basel, 1951.
11. P. J. G. Mann and J. H. Quastel, Biochem. J. 31, 869 (1937).
12. H. A. Rothschild, O. Cori, and E. S. G. Barron, /. Biol. Chem. 208, 717
(1954).
13. H. A. Rothschild and E. S. G. Barron, /. Biol. Chem. 209, 511 (1954).
14. J. A. Stekol, S. Weiss, and E. I. Anderson, /. Am. Chem. Soc. 77, 5192
(1955).
15. J. F. Nyc, /. Biol. Chem. 223, 811 (1956).
16. W. Sakami and A. D. Welch, /. Biol. Chem. 187, 379, (1950).
17. J. A. Stekol, E. I. Anderson, and S. Weiss, /. Biol. Chem. 233, 425 (1958).
18. B. N. Ames, /. Biol. Chem. 226, 583 (1957).
19. E. Adams, /. Biol. Chem. 217, 325 (1956).
G. L. CANTONI
VI. Conclusions
Although much remains to be learned, it is becoming evident that
onium compounds are an important group of naturally occurring compounds. The considerable range of their biological distribution, the
chemical and enzymatic reactivity conferred by the presence of the
onium pole, and the important physiological and pharmacological
effects elicited by some of these compounds all point to the need for
further explorations in the chemistry, biochemistry, and biology of these
interesting compounds.
ACKNOWLEDGMENTS
The author takes great pleasure in acknowledging the helpful discussions and
suggestions of Drs. S. H. Mudd, W. A. Klee, J. Durell, and a number of other
collaborators and colleagues at the National Institutes of Health, and in particular
he is grateful to Dr. G. A. Jamieson for discussion and advice on the more chemical
aspects of this review. Thankful acknowledgment is due to Journal of Biological
Chemistry, Biochemical Journal and Biochim. et Biophys. Acta for permission
to reproduce figures and tables as indicated.
References
1. G. W. Wheeland, "Advanced Organic Chemistry," 2nd ed. Wiley, New
York, 1953.
2. G. M. Bennet and A. W. Chapman. Ann. Repts. on Progr. Chem. (Chem.
Soc, London) p. 143 (1931).
3. P. B. D. de la Mare, Ann. Repts. on Progr. Chem. (Chem. Soc, London)
p. 134 (1950).
4. M. L. Dhar, E. D. Hughes, C. R. Ingold, K. M. M. Mandour, G. A. Maw,
and L. I. Woolf, /. Chem. Soc. p. 2093 (1948).
5. R. Willstätter, Ber. deut. ehem. Ges. 35, 584 (1902).
6. T. S. Stevens, E. M. Creighton, A. B. Gordon, and M. MacNicol, /. Chem.
Soc. p. 3193 (1928).
7. T. Thompson and T. S. Stevens, /. Chem. Soc. p. 69 (1932).
8. C. R. Hansen and S. W. Kantor, /. Am. Chem. Soc. 73, 4122 (1951).
9. A. J. Birch, R. J. English, R. A. Massy-Westoff, M. Slaytor, and H. Smith,
/. Chem. Soc. p. 365 (1958).
10. M. Guggenheim, "Die Biogenen Amine." Karger, Basel, 1951.
11. P. J. G. Mann and J. H. Quastel, Biochem. J. 31, 869 (1937).
12. H. A. Rothschild, O. Cori, and E. S. G. Barron, /. Biol. Chem. 208, 717
(1954).
13. H. A. Rothschild and E. S. G. Barron, /. Biol. Chem. 209, 511 (1954).
14. J. A. Stekol, S. Weiss, and E. I. Anderson, /. Am. Chem. Soc. 77, 5192
(1955).
15. J. F. Nyc, /. Biol. Chem. 223, 811 (1956).
16. W. Sakami and A. D. Welch, /. Biol. Chem. 187, 379, (1950).
17. J. A. Stekol, E. I. Anderson, and S. Weiss, /. Biol. Chem. 233, 425 (1958).
18. B. N. Ames, /. Biol. Chem. 226, 583 (1957).
19. E. Adams, /. Biol. Chem. 217, 325 (1956).