352
ORGANIC SYNTHESIS—1995
VI.A.7. Amino Acid Derivatives
VLA.7-1 Palomo, C. et al., CC, 1957; Ojima, I. et al., JOC, 59, 1249 and
TL, 35, 5785.
BnO.
R·
R
Î
'
H 2 N ^ X 0 2 B n
^ _ N
DMF,NaN 3 B o c N H
O
Boc
N
C0 2 Bn
OBn H
VI.A.7-2 O'Donnell, M.J. et al., TL, 35,9383.
AlMe 2
r
Me
3
AI
» M e ^ J \
R
Cp 2 ZrCl 2 *
X^H
R
Ph
P h \ ^ N ^ . C 0 2 R ·
Ph
OAc
]
Pd(Ph 3 P) 4
50-68 %
H 2 N. / C 0 2 R '
Ph
Me
R
HC1, Et 2 Q
75-89 %
HC1
Me
H
R
VI.A.7-3 Lundin, R.H.L. et al., TL, 35, 6339.
A Convenient Method for the Synthesis of Peptide Tnsulfides.
VI.A.7-4 Tang, W. et al., TL, 35, 6515.
Preparation of a New PEGylation Reagent for SulfhydrylContaining Polypeptide.