328
ORGANIC SYNTHESIS—1995
V.E-5 Giralt, E. et al., 7X, 35, 4437.
Solid-Phase Synthesis of Peptides Using Allylic Anchoring Groups
2. Palladium-Catalyzed Cleavage of Fmoc-Protected Peptides.
V.E-6 Chao, H.G. et al., JACS, 116, 1746.
A Novel and Versatile Silicon-Derived Linkage Agent, 4-[l-Hydroxy2-(trimethylsilyI)ethyl]benzoic Acid. Compatible with the Fmoc/l-Bu
Strategy for Solid-Phase Synthesis of C-Terminal Peptide Acids.
V.E-7 Rapoport, H. et al., JOC, 59, 3216; Joullie, M.M. et al., SC, 24, 187.
O
O
O
NHBoc
H C 1 NH 2
100%
V.E-8 Berkowitz, D.B. and Pedersen, M.L., JOC, 59, 5476.
Simultaneous Amino and Carboxyl Group Protection for aBranched Amino Acids.
V.E-9 Johnson, T. and Quibell, M., TL, 35,463.
OC
H-Ala-OH
^^
OH
H—(HBz)Ala—OH
NaBH 4 , KOH, aq EtOH
... _ _ ._ .
v
M
remove with TFMSA,
stable to TFA
ORGANIC SYNTHESIS—1995
V.E-5 Giralt, E. et al., 7X, 35, 4437.
Solid-Phase Synthesis of Peptides Using Allylic Anchoring Groups
2. Palladium-Catalyzed Cleavage of Fmoc-Protected Peptides.
V.E-6 Chao, H.G. et al., JACS, 116, 1746.
A Novel and Versatile Silicon-Derived Linkage Agent, 4-[l-Hydroxy2-(trimethylsilyI)ethyl]benzoic Acid. Compatible with the Fmoc/l-Bu
Strategy for Solid-Phase Synthesis of C-Terminal Peptide Acids.
V.E-7 Rapoport, H. et al., JOC, 59, 3216; Joullie, M.M. et al., SC, 24, 187.
O
O
O
NHBoc
H C 1 NH 2
100%
V.E-8 Berkowitz, D.B. and Pedersen, M.L., JOC, 59, 5476.
Simultaneous Amino and Carboxyl Group Protection for aBranched Amino Acids.
V.E-9 Johnson, T. and Quibell, M., TL, 35,463.
OC
H-Ala-OH
^^
OH
H—(HBz)Ala—OH
NaBH 4 , KOH, aq EtOH
... _ _ ._ .
v
M
remove with TFMSA,
stable to TFA