PROTECTING GROUPS
327
V.E. Amino Acid Protection
V.E-1 Pearson, A.J. and Lee, K., JOC, 59, 2257
Some Studies on the Uses of 2-Bromoethyl and 2-Iodoethyl Ester
Blocking Groups in Peptide Synthesis: Samarium Diiodide
Mediated Deprotection.
V.E-2 Samukov, V.V. et al., TL, 35, 7821.
2-(4-Nitrophenyl)sulfonylethoxycarbonyl (Nsc) Group as a BaseLabile a-Amino Protection for Solid Phase Peptide Synthesis.
V.E-3 Richter, L.S. et al., TU 35, 1631.
/
S ^ l
1: EtsSiH, TFA, CH 2 CI 2
^
S ^ /
A r
Α Γ
~ ~ Λ A
2: Boc 2 0
"* Jf
N
" ^ 0 2 H
B o c N ^ C 0 2 H
H
H
81-82 %
V.E-4 Shapiro, G. and Buechler, D., TL, 35, 5421.
H
Boc O
fin
H
o
TMSN 3 , BU4NF
Pd(PPh 3 ) 4 , CH 2 CI 2 ,
-Resin
7Γ H
Boc O
Bn
ncm
>95%
327
V.E. Amino Acid Protection
V.E-1 Pearson, A.J. and Lee, K., JOC, 59, 2257
Some Studies on the Uses of 2-Bromoethyl and 2-Iodoethyl Ester
Blocking Groups in Peptide Synthesis: Samarium Diiodide
Mediated Deprotection.
V.E-2 Samukov, V.V. et al., TL, 35, 7821.
2-(4-Nitrophenyl)sulfonylethoxycarbonyl (Nsc) Group as a BaseLabile a-Amino Protection for Solid Phase Peptide Synthesis.
V.E-3 Richter, L.S. et al., TU 35, 1631.
/
S ^ l
1: EtsSiH, TFA, CH 2 CI 2
^
S ^ /
A r
Α Γ
~ ~ Λ A
2: Boc 2 0
"* Jf
N
" ^ 0 2 H
B o c N ^ C 0 2 H
H
H
81-82 %
V.E-4 Shapiro, G. and Buechler, D., TL, 35, 5421.
H
Boc O
fin
H
o
TMSN 3 , BU4NF
Pd(PPh 3 ) 4 , CH 2 CI 2 ,
-Resin
7Γ H
Boc O
Bn
ncm
>95%