PROTECTING GROUPS
319
V.A-16 Wincott, F.E. and Usman, N., TL, 35, 6827.
2'-(Trimethylsilyl)ethoxymethyl Protection of the 2'-HydroxyI
Group in Oligoribonucleotide Synthesis.
V.A-17 Tanabe, Y. et al., TL, 35, 8409 and 8413; Gregg, B.T. and Cutler,
A.R., OM, 13, 1039.
R - O H
f
N-TMS
TBAF (cat)
R-OTMS
V.A-18 Scharf, H.D. et al., LA, 775; Ziegler, T., TL, 35, 6857; Hodosi, G.,
TL, 35, 6129; Ley, S.V. et al., TL, 35, 773 and 777.
.O.
O
.o
o
SQ 2 Ph
O
HO
OH
BF 3 -OEt 2
o. p
85%
V.A-19 Kang, S. et al., SC, 24, 305.
OH
OH
BnO N
OH
(Cl 3 CO) 2 CO
pyr
*
BnO
OH