10
ORGANIC SYNTHESIS—1995
I.A.3-3 Rayner, CM. et al., CC, 2597.
1) NaH, DME
R
1 ^ "Y" "OR
3
_ r—v α,^Γ
R
1 " "X" "OR
J
R
2
I.A.3-4 Thomas, H.G. et al., CB, 127, 1257.
,C0 2 R>
,.
f» ** f ° '
R 2
R'-CH
► R
1
—C
C—R
1
CO R
2
MeCN
1 , 1 ,
c o 2
K
C0 2 R
2
C0 2 R
2
9-90%
I.A.3-5 Tanner, D. et al., TL, 35, 4631; Kubota, H. and Koga, K., TL,
35, 6689; Helmchen, G. et al., TL, 35, 8595; Trost, B.M. et al., TL, 35,
5817; Akermark, B., Vitagliano, A. et al., OM, 13, 1963.
Ac
ÇH(C0 2 Me) 2
NaCH(C0 2 Me) 2
!
P h " ^
^
P h
Pd(II),cat.
*
P t ^ ^ P h
89%,>99%ee
F K
A Ph
cat. =
Pif
''Ph
similar reactions reported with other chiral ligands