501. «Diététique pratique et Gastronomique du
au VeteransAdministraüon Medical Center, Uni—
Sportif ’ Dr J.L. VIDALO Ed. Maloine —l 985
versity of South Florida, Tampa.
502.Mark MattsOn, Laboratory of Neurosciences,
508 Journal ofNeuroscience, 15/07/2002.
.
National Institute on Aging (NM), National Ins—
509. Carmelina Gemma, Michael H. Mesches, Boris
titutes of Health, USA.
_
Sepesi, Kevin Choc, Douglas B. Holmes, and
505. Hypothèse formulée en 1954 par l’Américain
Paula C. Bickford : Diets Enriched in Foods with
Denham Harman, père de la théorie du vieillisse—
'
HighAntioxîdant Activity Reverse Age—Induced
ment par les radicaux libres: Harman D : Agi‘ng:
Decreases in Cerebellar -Adrenergic Function
a theory based on free radical and radiation cheand lncreases in Proinammatory Cytokines, J.
mistry, J Gerontol, 1956, l 1 :289-3 00. Leibovitz
Neurosci. 2002 22 : 6114—6120.
BE&BV Siegel:Aspects offree radicalreactions
510. WangY, CF Chang, J Chou, HLChen,XDeng,
-
in biological systems : -aging, J Gerontol., 1980,
BK Harvey, JL Cadet, PC Bickford: Dietary sup35 :45—56. Des chercheurs italiens conrmmt que
plementation Withbluebenies, spinach, or Spiru’
« L’accumulatiOn de dégâts oXydatifs inigés
linareduces iSChemic brain damage, Exp Neuro].
par les radicaux libres et les espèces réactives de
2005 May; 193(1):75-84. Stromberg I, C Gemma,
.
l’oxygèneest la cause majeure la plus vraisem—
J Vila, PC Bickford: Blueberry and spirulina—en"
blable du vieillissement tant chez les invertébrés
riched diets enhance striatal dopamine recovery
'
que chez les mammifères »: Mighaccio, B: The
and inducea rapid, transient microglia activation
p6ôshc adaptor protein controls oxidative stress
aer injury ofthe rat nigrostriatal dopamine sys—
,
response andlife span in ma1nmàls, Nature, 1999,
tem, ExpNeurol, 2005 Dec;196(2):2984307.
3 2 5
‘
402: 309—313. ’ ’
"
-
5 1 1.- Cartford C, Gemma C & Bickford PC:
'»
304. Taub J, JF Lau, C Ma, JH Hahn, R Hoque, J
Eighteen—Month—Old Fischer 344 Rats Fed a
Rothblatt, M Chale : A Cytosolic catalase is neeSpinach—Enriched Diet Show Improved Delay
ded to extend adult lifespan in C. elegans daf-C
Classical Eyeblink Conditioning and Reduced
and clk—1 mutants, Nature, 1999, 399:162=166.
EXpression of Tumor Necrosis Factor alpha
305. Ames BN, MK Shigenaga,TM Hagen: Oxi—
(”INF—alpha) and INF—beta inthe Cerebellum,
Z
dants, anoxidants, and the degeueætive diseases
.
The Journal ofNeuroscience, July 15, 2002,
O
’
ofaging,ProcNaAcad Sci USA, 1993, 901791522(‘l4)158l3-5816
'
'
'
e—r
7922. Cao G,'E Soc, RL Prior: Anoxidant
512. Bickford PC, T Gould, L Bedeclç, K ChadŒ
capacity of tea'and commœ vegetables, ] Agde
man, A Pollock, D Young, B ShŒû—Hale, J JoFood Chem. 1996, 44 :3426—343 1. Cao G,-RM
seph: Antioxidant—rjch diets improve cerebellar
g
Russell, N Lischner, RL Prior : Serum antioxi—
<“
physiology and motor learningin aged rats, Brain
î
'
dant capacity'is increased by consumption of
Res. 2000, 866 211—217.
’
'
6'
strawbenies, spinach, red wine, or vitamin C in
5 15. J Warsama J ama, LJ. Launer, JCM \V1tteman,
LQ
elderly women, J Nutr, 1998, 128 :23 83-23901,
_
J H den Breeijen, MMB Breteler, DE Grobbee
a
Chen YC, SC Shen, WR Lee, WC Hou, LLYang,
& A Hofman: Dietary Anüoxidants and Cogni—
“O
TJF Lee : Inhibition ofnitric oxide synthase inhitive Function in
Sample of
3—
bitors and lipopolysacchade induced inducible
Older Persons: The Rotterdam Study, Am. J.
5
NOS and Cyclooxygenase—2 gene expressions
-
Epidemiol. 1996, 1442275—280.Audæs—Lacue—
:
by lutin, quercetin and quercetin pentaacetate
Va C, B Shukitt—Hale, RL Galli, 0 Jauregui, RM
(D
RAW 264.7 macrophages, J—Cell Biochem,
Lamuela—Raventos, JA Joseph: Anthocyanins in
m
2001, 82 :537—548. Galli RL, DF Bielinski, A
aged blueberry—fed rats are found cenüally and
Szprengiel, B Shukithale, JAJoseph : Bluebeny ,
may enhance memory, Nutr Neurosci. 2005 Apr;
supplemented diet reverses age—related decline in
8(2): 1 1 1 —20.
hippocampal HSP7O neuroprotecon,Næmbiol
514. [Stromberg I et al.: Blueberry— and spirulina—
Aging, 2006 Feb;27(2):344—50.
,
enched diets enhance striatal dopaminerecovery
506. Vatassery G : Vitamjn E and other endogenous
and induce a rapid, transient microglia activation
an6xidants in the central nervous system, Geria—
'
after injury ofthe rat nigrosüiatal dopamine sys—
trics, September 1998; 53(1); SZS-S7. Further—
tem, Exp Neuro]. 196, 2 :298—307, 2005.
more, brain trauma and injury tends to increase
5 15. Wang Y et al. Dieta1y supplementation with
Whole—bodyoxidative stress. Shohami E et al.:
bluebenies, spinach, or spirulina reduces ischemio
Closed head'injury in the rat induces whole body
brain damage, Exp Neurol. 193, 1 :75—84, 2005.
stress
overall reducing‘antioxidant
5
A & J Walker;
A multi—axial treat—
prole, Journal of Neurotrauma, May 1999;
ment paradigm for mild traumatic brain injury
l6(5):365—76.
'
to achieve reparative mctional metaplasticity,
507. Paula Bickford, professeur au Department of
Paperpresented at the Third World Congress on
Neurosurgery, Center for Aging‘ & Brain Repair
Brain Ilÿlüy,‘ June 1999; Quebec City, Canada.
6
__—
au VeteransAdministraüon Medical Center, Uni—
Sportif ’ Dr J.L. VIDALO Ed. Maloine —l 985
versity of South Florida, Tampa.
502.Mark MattsOn, Laboratory of Neurosciences,
508 Journal ofNeuroscience, 15/07/2002.
.
National Institute on Aging (NM), National Ins—
509. Carmelina Gemma, Michael H. Mesches, Boris
titutes of Health, USA.
_
Sepesi, Kevin Choc, Douglas B. Holmes, and
505. Hypothèse formulée en 1954 par l’Américain
Paula C. Bickford : Diets Enriched in Foods with
Denham Harman, père de la théorie du vieillisse—
'
HighAntioxîdant Activity Reverse Age—Induced
ment par les radicaux libres: Harman D : Agi‘ng:
Decreases in Cerebellar -Adrenergic Function
a theory based on free radical and radiation cheand lncreases in Proinammatory Cytokines, J.
mistry, J Gerontol, 1956, l 1 :289-3 00. Leibovitz
Neurosci. 2002 22 : 6114—6120.
BE&BV Siegel:Aspects offree radicalreactions
510. WangY, CF Chang, J Chou, HLChen,XDeng,
-
in biological systems : -aging, J Gerontol., 1980,
BK Harvey, JL Cadet, PC Bickford: Dietary sup35 :45—56. Des chercheurs italiens conrmmt que
plementation Withbluebenies, spinach, or Spiru’
« L’accumulatiOn de dégâts oXydatifs inigés
linareduces iSChemic brain damage, Exp Neuro].
par les radicaux libres et les espèces réactives de
2005 May; 193(1):75-84. Stromberg I, C Gemma,
.
l’oxygèneest la cause majeure la plus vraisem—
J Vila, PC Bickford: Blueberry and spirulina—en"
blable du vieillissement tant chez les invertébrés
riched diets enhance striatal dopamine recovery
'
que chez les mammifères »: Mighaccio, B: The
and inducea rapid, transient microglia activation
p6ôshc adaptor protein controls oxidative stress
aer injury ofthe rat nigrostriatal dopamine sys—
,
response andlife span in ma1nmàls, Nature, 1999,
tem, ExpNeurol, 2005 Dec;196(2):2984307.
3 2 5
‘
402: 309—313. ’ ’
"
-
5 1 1.- Cartford C, Gemma C & Bickford PC:
'»
304. Taub J, JF Lau, C Ma, JH Hahn, R Hoque, J
Eighteen—Month—Old Fischer 344 Rats Fed a
Rothblatt, M Chale : A Cytosolic catalase is neeSpinach—Enriched Diet Show Improved Delay
ded to extend adult lifespan in C. elegans daf-C
Classical Eyeblink Conditioning and Reduced
and clk—1 mutants, Nature, 1999, 399:162=166.
EXpression of Tumor Necrosis Factor alpha
305. Ames BN, MK Shigenaga,TM Hagen: Oxi—
(”INF—alpha) and INF—beta inthe Cerebellum,
Z
dants, anoxidants, and the degeueætive diseases
.
The Journal ofNeuroscience, July 15, 2002,
O
’
ofaging,ProcNaAcad Sci USA, 1993, 901791522(‘l4)158l3-5816
'
'
'
e—r
7922. Cao G,'E Soc, RL Prior: Anoxidant
512. Bickford PC, T Gould, L Bedeclç, K ChadŒ
capacity of tea'and commœ vegetables, ] Agde
man, A Pollock, D Young, B ShŒû—Hale, J JoFood Chem. 1996, 44 :3426—343 1. Cao G,-RM
seph: Antioxidant—rjch diets improve cerebellar
g
Russell, N Lischner, RL Prior : Serum antioxi—
<“
physiology and motor learningin aged rats, Brain
î
'
dant capacity'is increased by consumption of
Res. 2000, 866 211—217.
’
'
6'
strawbenies, spinach, red wine, or vitamin C in
5 15. J Warsama J ama, LJ. Launer, JCM \V1tteman,
LQ
elderly women, J Nutr, 1998, 128 :23 83-23901,
_
J H den Breeijen, MMB Breteler, DE Grobbee
a
Chen YC, SC Shen, WR Lee, WC Hou, LLYang,
& A Hofman: Dietary Anüoxidants and Cogni—
“O
TJF Lee : Inhibition ofnitric oxide synthase inhitive Function in
Sample of
3—
bitors and lipopolysacchade induced inducible
Older Persons: The Rotterdam Study, Am. J.
5
NOS and Cyclooxygenase—2 gene expressions
-
Epidemiol. 1996, 1442275—280.Audæs—Lacue—
:
by lutin, quercetin and quercetin pentaacetate
Va C, B Shukitt—Hale, RL Galli, 0 Jauregui, RM
(D
RAW 264.7 macrophages, J—Cell Biochem,
Lamuela—Raventos, JA Joseph: Anthocyanins in
m
2001, 82 :537—548. Galli RL, DF Bielinski, A
aged blueberry—fed rats are found cenüally and
Szprengiel, B Shukithale, JAJoseph : Bluebeny ,
may enhance memory, Nutr Neurosci. 2005 Apr;
supplemented diet reverses age—related decline in
8(2): 1 1 1 —20.
hippocampal HSP7O neuroprotecon,Næmbiol
514. [Stromberg I et al.: Blueberry— and spirulina—
Aging, 2006 Feb;27(2):344—50.
,
enched diets enhance striatal dopaminerecovery
506. Vatassery G : Vitamjn E and other endogenous
and induce a rapid, transient microglia activation
an6xidants in the central nervous system, Geria—
'
after injury ofthe rat nigrosüiatal dopamine sys—
trics, September 1998; 53(1); SZS-S7. Further—
tem, Exp Neuro]. 196, 2 :298—307, 2005.
more, brain trauma and injury tends to increase
5 15. Wang Y et al. Dieta1y supplementation with
Whole—bodyoxidative stress. Shohami E et al.:
bluebenies, spinach, or spirulina reduces ischemio
Closed head'injury in the rat induces whole body
brain damage, Exp Neurol. 193, 1 :75—84, 2005.
stress
overall reducing‘antioxidant
5
A & J Walker;
A multi—axial treat—
prole, Journal of Neurotrauma, May 1999;
ment paradigm for mild traumatic brain injury
l6(5):365—76.
'
to achieve reparative mctional metaplasticity,
507. Paula Bickford, professeur au Department of
Paperpresented at the Third World Congress on
Neurosurgery, Center for Aging‘ & Brain Repair
Brain Ilÿlüy,‘ June 1999; Quebec City, Canada.
6
__—