Larkin P, Scowcroft W (1981) Somaclonal variation—a novel source of variability from cell
cultures for plant improvement. Theor Appl Genet 60:197–214
Leite A, Kemper EL, da Silva MJ, Luchessi AD, Siloto RMP, Bonaccorsi ED, El-Dorry HF,
Arruda P (2000) Expression of correctly processed human growth hormone in seeds of
transgenic tobacco plants. Mol Breed 6:47–53
Li JWH, Vederas JC (2009) Drug discovery and natural products: end of an era or an endless
frontier? Science 325:161–165
Lim EK, Bowles D (2012) Plant production systems for bioactive small molecules. Curr Opin
Biotechnol 23:271–277
Liu YG, Shirano Y, Fukaki H, Yanai Y, Tasaka M, Tabata S, Shibata D (1999) Complementation
of plant mutants with large genomic DNA fragments by a transformation-competent artificial
chromosome vector accelerates positional cloning. Proc Nat Acad Sci USA 96:6535–6540
López-Arredondo DL, Herrera-Estrella L (2012) Engineering phosphorus metabolism in plants to
produce a dual fertilization and weed control system. Nat Biotechnol 30:889–893
Lu S, Van Eck J, Zhou X, Lopez A, O’Halloran D, Cosman B, Conlin D, Paolillo B, Garvin D,
Vrebalov J, Kochian V, Kupper H, Earle E, Cao J, Lia L (2006) The cauliflower Or gene
encodes a DnaJ cysteine-rich domain containing protein that mediates high levels of
b-carotene accumulation. Plant Cell 18:3594–3605
Ma JK, Hiatt A, Hein M, Vine ND, Wang F, Stabila P, van Dolleweerd C, Mostov K, Lehner T
(1995) Generation and assembly of secretory antibodies in plants. Science 268:716–719
Ma JK, Drake PM, Chargelegue D, Obregon P, Prada A (2005) Antibody processing and
engineering in plants, and new strategies for vaccine production. Vaccine 23:1814–1818
Maia MF, Moore SJ (2011) Plant-based insect repellents: a review of their efficacy, development
and testing. Malaria J 10:S11. doi:10.1186/1475-2875-10-S1-S11
Martin C, Butelli E, Petroni K, Tonelli Ch (2011) How can research on plants contribute to
promoting human health? Plant Cell 23:1685–1699
Mathur A, Gangwar A, Mathur AK, Verma P, Uniyal GC, Lal RK (2010) Growth kinetics and
ginsenosides production in transformed hairy roots of American ginseng- Panax quinquefolium L. Biotechnol Lett 32:457–461
Mayfield SP, Franklin SE (2005) Expression of human antibodies in eukaryotic micro-algae.
Vaccine 23:1828–1832
McCormick AA, Kumagai MH, Hanley K, Turpen TH, Hakim I, Grill LK, Tuse D, Levy A, Levy
R (1999) Rapid production of specific vaccines for lymphoma by expression of the tumorderived single-chain Fv epitopes in tobacco plants. Proc Nat Acad Sci USA 96:703–708
Menke FL, Champion A, Kijne JW, Memelink J (1999) A novel jasmonate-and elicitorresponsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts
with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2. EMBO J
18:4455–4463
Miralpeix B, Rischer H, Häkkinen ST, Ritala A, Seppänen-Laakso T, Oksman-Caldentey KM,
Capell T, Christou P (2013) Metabolic engineering of plant secondary metabolites: wich way
the forward? Curr Pharm Des 19:5622–5639
Mitsuda N, Hiratsu K, Todaka D, Nakashima K, Yamaguchi-Shinozaki K, Ohme-Takagi M
(2006) Efficient production of male and female sterile plants by expression of a chimeric
repressor in Arabidopsis and rice. Plant Biotechnol J 4:325–332
Molina A, Hervaas-Stubbs S, Daniell H, Mingo-Castel AM, Veramendi J (2004) High-yield
expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. Plant
Biotechnol J 2:141–153
Moon-Yoon J, Zhao LY, Shanks JV (2013) Metabolic engineering with plants for a sustainable
biobased economy. Ann Rev Chem Biomol Eng 4:211–237
Nandi S, Suzuki YA, Huang J, Yalda D, Pham P, Liying W, Bartley G, Ning H, Lonnerdal B
(2002) Expression of human lactoferrin in transgenic rice grains for the application in infant
formula. Plant Sci 163:713–722
450
L. A. Cruz-Ramírez et al.
cultures for plant improvement. Theor Appl Genet 60:197–214
Leite A, Kemper EL, da Silva MJ, Luchessi AD, Siloto RMP, Bonaccorsi ED, El-Dorry HF,
Arruda P (2000) Expression of correctly processed human growth hormone in seeds of
transgenic tobacco plants. Mol Breed 6:47–53
Li JWH, Vederas JC (2009) Drug discovery and natural products: end of an era or an endless
frontier? Science 325:161–165
Lim EK, Bowles D (2012) Plant production systems for bioactive small molecules. Curr Opin
Biotechnol 23:271–277
Liu YG, Shirano Y, Fukaki H, Yanai Y, Tasaka M, Tabata S, Shibata D (1999) Complementation
of plant mutants with large genomic DNA fragments by a transformation-competent artificial
chromosome vector accelerates positional cloning. Proc Nat Acad Sci USA 96:6535–6540
López-Arredondo DL, Herrera-Estrella L (2012) Engineering phosphorus metabolism in plants to
produce a dual fertilization and weed control system. Nat Biotechnol 30:889–893
Lu S, Van Eck J, Zhou X, Lopez A, O’Halloran D, Cosman B, Conlin D, Paolillo B, Garvin D,
Vrebalov J, Kochian V, Kupper H, Earle E, Cao J, Lia L (2006) The cauliflower Or gene
encodes a DnaJ cysteine-rich domain containing protein that mediates high levels of
b-carotene accumulation. Plant Cell 18:3594–3605
Ma JK, Hiatt A, Hein M, Vine ND, Wang F, Stabila P, van Dolleweerd C, Mostov K, Lehner T
(1995) Generation and assembly of secretory antibodies in plants. Science 268:716–719
Ma JK, Drake PM, Chargelegue D, Obregon P, Prada A (2005) Antibody processing and
engineering in plants, and new strategies for vaccine production. Vaccine 23:1814–1818
Maia MF, Moore SJ (2011) Plant-based insect repellents: a review of their efficacy, development
and testing. Malaria J 10:S11. doi:10.1186/1475-2875-10-S1-S11
Martin C, Butelli E, Petroni K, Tonelli Ch (2011) How can research on plants contribute to
promoting human health? Plant Cell 23:1685–1699
Mathur A, Gangwar A, Mathur AK, Verma P, Uniyal GC, Lal RK (2010) Growth kinetics and
ginsenosides production in transformed hairy roots of American ginseng- Panax quinquefolium L. Biotechnol Lett 32:457–461
Mayfield SP, Franklin SE (2005) Expression of human antibodies in eukaryotic micro-algae.
Vaccine 23:1828–1832
McCormick AA, Kumagai MH, Hanley K, Turpen TH, Hakim I, Grill LK, Tuse D, Levy A, Levy
R (1999) Rapid production of specific vaccines for lymphoma by expression of the tumorderived single-chain Fv epitopes in tobacco plants. Proc Nat Acad Sci USA 96:703–708
Menke FL, Champion A, Kijne JW, Memelink J (1999) A novel jasmonate-and elicitorresponsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts
with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2. EMBO J
18:4455–4463
Miralpeix B, Rischer H, Häkkinen ST, Ritala A, Seppänen-Laakso T, Oksman-Caldentey KM,
Capell T, Christou P (2013) Metabolic engineering of plant secondary metabolites: wich way
the forward? Curr Pharm Des 19:5622–5639
Mitsuda N, Hiratsu K, Todaka D, Nakashima K, Yamaguchi-Shinozaki K, Ohme-Takagi M
(2006) Efficient production of male and female sterile plants by expression of a chimeric
repressor in Arabidopsis and rice. Plant Biotechnol J 4:325–332
Molina A, Hervaas-Stubbs S, Daniell H, Mingo-Castel AM, Veramendi J (2004) High-yield
expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts. Plant
Biotechnol J 2:141–153
Moon-Yoon J, Zhao LY, Shanks JV (2013) Metabolic engineering with plants for a sustainable
biobased economy. Ann Rev Chem Biomol Eng 4:211–237
Nandi S, Suzuki YA, Huang J, Yalda D, Pham P, Liying W, Bartley G, Ning H, Lonnerdal B
(2002) Expression of human lactoferrin in transgenic rice grains for the application in infant
formula. Plant Sci 163:713–722
450
L. A. Cruz-Ramírez et al.