Cunningham FX Jr, Gantt E (2001) One ring or two? Determination of ring number in
carotenoids by lycopene e-cyclases. Proc Nat Acad Sci USA 98:2905–2910
Cunningham FX Jr, Chamovitz D, Misawa N, Gantt E, Hirschberg J (1993) Molecular cloning
and expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme
that catalyzes the biosynthesis of b-carotene. FEBS Lett 328:130–138
De Cosa B, Moar W, Lee SB, Miller M, Daniell H (2001) Overexpression of the Bt cry2Aa2
operon in chloroplasts leads to formation of insecticidal crystals. Nat Biotechnol 19:71–74
De Groote ML, Verschure PJ, Rots MG (2012) Epigenetic Editing: targeted rewriting of
epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res
40:10596–10613
De Jaeger G, De Wilde C, Eeckhout D, Fiers E, Depicker A (2000) The plantibody approach:
expression of antibody genes in plants to modulate plant metabolism or to obtain pathogen
resistance. Plant Mol Biol 43:419–428
Decker EL, Reski R (2004) The moss bioreactor. Curr Opin Plant Biol 7:166–170
Decker EL, Reski R (2007) Moss bioreactors producing improved biopharmaceuticals. Curr Opin
Biotech 18:393–398
DellaPenna D (2001) Plant metabolic engineering. Plant Physiol 125:160–163
Dixon RA (2005) Engineering of plant natural product pathways. Curr Opin Plant Biol 8:329–336
Farré G, Bai C, Twyman RM, Capell T, Christou P, Zhu C (2011) Nutritious crops producing
multiple carotenoids–a metabolic balancing act. Trends Plant Sci 16:532–540
Feng S, Jacobsen SE (2011) Epigenetic modifications in plants: an evolutionary perspective. Curr
Opin Plant Biol 14:179–186
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC (1998) Potent and specific
genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806–811
Floss DM, Schallau K, Rose-John S, Conrad U, Scheller J (2010) Elastin-like polypeptides
revolutionize recombinant protein expression and their biomedical application. Trends
Biotechnol 28:37–45
Forkmann G, Martens S (2001) Metabolic engineering and applications of flavonoids. Curr Opin
Biotechnol 12:155–160
Gao J, Hooker BS, Anderson DB (2004) Expression of functional human coagulation factor XIII
A-domain in plant cell suspensions and whole plants. Protein Exp Purif 37:89–96
Georgiev VG, Weber J, Kneschke EM, Denev PN, Bley T, Pavlov AI (2010) Antioxidant activity
and phenolic content of betalain extracts from intact plants and hairy root cultures of the red
beetroot Beta vulgaris cv. detroit dark red. Plant Foods Hum Nutr 65:105–111
Giuliano G, Bartley GE, Scolnik PA (1993) Regulation of carotenoid biosynthesis during tomato
development. Plant Cell 5:379–387
Goldschmidt-Clermont M, Day A (2011) The chroplast transformation toolbox: selectable
markers removal. Plant Biotechnol J 9:540–553
Goosens A, Häkkinen ST, Laakso I, Seppanen-Laakso T, Blondi S, De Sutter V, Lammertyn F
et al (2003) A functional genomics approach toward understanding of secondary metabolism
in plant cells. Proc Nat Acad Sci USA 100:8595–8600
Grabkowska R, Krolicka A, Mielicki W, Wielanek M, Wysokinska H (2010) Genetic
transformation of Harpagophytum procumbens by Agrobacterium rhizogenes: iridoid and
phenylethanoid glycoside accumulation in hairy root cultures. Acta Physiol Plant 32:665–673
Grotewold E (2008) Transcription factors for predictive plant metabolic engineering: are we there
yet? Curr Opin Biotechnol 19:138–144
Grotewold E, Chamberlin M, Snook M, Siame B, Butler L, Swenson J, Maddock S, St Clair G,
Bowen B (1998) Engineering secondary metabolism in maize cells bye ectopic expression of
transcription factors. Plant Cell 10:721–740
Grusak MA, DellaPenna D (1999) Improving the nutrient composition of plants to enhance
human nutrition and health. Ann Rev Plant Biol 50:133–161
Guda C, Lee SB, Daniell H (2000) Stable expression of a biodegradable protein-based polymer in
tobacco chloroplasts. Plant Cell Rep 19:257–262
448
L. A. Cruz-Ramírez et al.
carotenoids by lycopene e-cyclases. Proc Nat Acad Sci USA 98:2905–2910
Cunningham FX Jr, Chamovitz D, Misawa N, Gantt E, Hirschberg J (1993) Molecular cloning
and expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme
that catalyzes the biosynthesis of b-carotene. FEBS Lett 328:130–138
De Cosa B, Moar W, Lee SB, Miller M, Daniell H (2001) Overexpression of the Bt cry2Aa2
operon in chloroplasts leads to formation of insecticidal crystals. Nat Biotechnol 19:71–74
De Groote ML, Verschure PJ, Rots MG (2012) Epigenetic Editing: targeted rewriting of
epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res
40:10596–10613
De Jaeger G, De Wilde C, Eeckhout D, Fiers E, Depicker A (2000) The plantibody approach:
expression of antibody genes in plants to modulate plant metabolism or to obtain pathogen
resistance. Plant Mol Biol 43:419–428
Decker EL, Reski R (2004) The moss bioreactor. Curr Opin Plant Biol 7:166–170
Decker EL, Reski R (2007) Moss bioreactors producing improved biopharmaceuticals. Curr Opin
Biotech 18:393–398
DellaPenna D (2001) Plant metabolic engineering. Plant Physiol 125:160–163
Dixon RA (2005) Engineering of plant natural product pathways. Curr Opin Plant Biol 8:329–336
Farré G, Bai C, Twyman RM, Capell T, Christou P, Zhu C (2011) Nutritious crops producing
multiple carotenoids–a metabolic balancing act. Trends Plant Sci 16:532–540
Feng S, Jacobsen SE (2011) Epigenetic modifications in plants: an evolutionary perspective. Curr
Opin Plant Biol 14:179–186
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC (1998) Potent and specific
genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806–811
Floss DM, Schallau K, Rose-John S, Conrad U, Scheller J (2010) Elastin-like polypeptides
revolutionize recombinant protein expression and their biomedical application. Trends
Biotechnol 28:37–45
Forkmann G, Martens S (2001) Metabolic engineering and applications of flavonoids. Curr Opin
Biotechnol 12:155–160
Gao J, Hooker BS, Anderson DB (2004) Expression of functional human coagulation factor XIII
A-domain in plant cell suspensions and whole plants. Protein Exp Purif 37:89–96
Georgiev VG, Weber J, Kneschke EM, Denev PN, Bley T, Pavlov AI (2010) Antioxidant activity
and phenolic content of betalain extracts from intact plants and hairy root cultures of the red
beetroot Beta vulgaris cv. detroit dark red. Plant Foods Hum Nutr 65:105–111
Giuliano G, Bartley GE, Scolnik PA (1993) Regulation of carotenoid biosynthesis during tomato
development. Plant Cell 5:379–387
Goldschmidt-Clermont M, Day A (2011) The chroplast transformation toolbox: selectable
markers removal. Plant Biotechnol J 9:540–553
Goosens A, Häkkinen ST, Laakso I, Seppanen-Laakso T, Blondi S, De Sutter V, Lammertyn F
et al (2003) A functional genomics approach toward understanding of secondary metabolism
in plant cells. Proc Nat Acad Sci USA 100:8595–8600
Grabkowska R, Krolicka A, Mielicki W, Wielanek M, Wysokinska H (2010) Genetic
transformation of Harpagophytum procumbens by Agrobacterium rhizogenes: iridoid and
phenylethanoid glycoside accumulation in hairy root cultures. Acta Physiol Plant 32:665–673
Grotewold E (2008) Transcription factors for predictive plant metabolic engineering: are we there
yet? Curr Opin Biotechnol 19:138–144
Grotewold E, Chamberlin M, Snook M, Siame B, Butler L, Swenson J, Maddock S, St Clair G,
Bowen B (1998) Engineering secondary metabolism in maize cells bye ectopic expression of
transcription factors. Plant Cell 10:721–740
Grusak MA, DellaPenna D (1999) Improving the nutrient composition of plants to enhance
human nutrition and health. Ann Rev Plant Biol 50:133–161
Guda C, Lee SB, Daniell H (2000) Stable expression of a biodegradable protein-based polymer in
tobacco chloroplasts. Plant Cell Rep 19:257–262
448
L. A. Cruz-Ramírez et al.