433
Behra M, Bradsher J, Sougrat R, Gallardo V, Allende ML, Burgess SM (2009) Phoenix is required
for mechanosensory hair cell regeneration in the zebrafi sh lateral line. PLoS Genet 5(4),
e1000455
Bhandiwad AA, Zeddies DG, Raible DW, Rubel EW, Sisneros JA (2013) Auditory sensitivity of
larval zebrafi sh ( Danio rerio ) measured using a behavioral prepulse inhibition assay. J Exp Biol
216(18):3504–3513
Blechinger SR, Kusch RC, Haugo K, Matz C, Chivers DP, Krone PH (2007) Brief embryonic
cadmium exposure induces a stress response and cell death in the developing olfactory system
followed by long-term olfactory defi cits in juvenile brafi sh. Toxicol Appl Pharmacol
224(1):72–80
Bleckmann H, Zelick R (2009) Lateral line system of fi sh. Integr Zool 4(1):13–25
Brack CL, Ramcharitar J (2012) Assessment of lateral line function: a potential technique for studies on ototoxicity. J Clin Neurosci 19:333–335
Braun CB, Coombs S (2000) The overlapping role of the inner ear and lateral line: the active space
of dipole source detection. Philos Trans R Soc Lond 355:1115–1119
Brignull HR, Raible DW, Stone JS (2009) Feathers and fi ns: non-mammalian models for hair cell
regeneration. Brain Res 1277:12–23
Brown AD, Mussen TD, Sisneros JA, Coffi n AB (2011) Reevaluating the use of aminoglycoside
antibiotics in behavioral studies of the lateral line. Hear Res 272(1–2):1–4
Buck LMJ, Winter MJ, Redfern WS, Whitfi eld TT (2012) Ototoxin-induced cellular damage in
neuromasts disrupts lateral line function in larval zebrafi sh. Hear Res 284:67–81
Chang JSY, Popper AN, Saidel WM (1992) Heterogeneity of sensory hair cells in a fi sh ear.
J Comp Neurol 324:621–640
Cheng AG, Cunningham LL, Rubel EW (2005) Mechanisms of hair cell death and protection. Curr
Opin Otolaryngol Head Neck Surg 13(6):343–348
Chiu LL, Cunningham LL, Raible DW, Rubel EW, Ou HC (2008) Using the zebrafi sh lateral line
to screen for ototoxicity. J Assoc Res Otolaryngol 9(2):178–190
Coffi n AB, Kelley MW, Manley GA, Popper AN (2004) Evolution of sensory hair cells. In: Manley
GA, Fay RR, Popper AN (eds) Evolution of the auditory system. Springer-Verlag, New York
Coffi n AB, Ou H, Owens KN, Santos F, Simon JA, Rubel EW, Raible DW (2010) Chemical
screening for hair cell loss and protection in the zebrafi sh lateral line. Zebrafi sh 7(1):3–11
Coffi n AB, Rubel EW, Raible DW (2013a) Bax, Bcl2, and p53 differentially regulate neomycinand gentamicin-induced hair cell death in the zebrafi sh lateral line. J Assoc Res Otolaryngol.
doi: 10.1007/s10162-013-0404-1
Coffi n AB, Williamson KL, Mamiya A, Raible DW, Rubel EW (2013b) Profi ling drug-induced cell
death pathways in the zebrafi sh lateral line. Apoptosis. doi: 10.1007/s10495-013-0816-8
Coffi n AB, Zeddies DG, Fay RR, Brown AD, Alderks PW, Bhandiwad AA, Mohr RA, Gray MD,
Rogers PH, Sisneros JA (2014a) Use of the swim bladder and lateral line in near-fi eld sound
source localization by fi shes. J Exp Biol. doi: 10.1242/jeb.093831
Coffi n AB, Brignull H, Raible DW, Rubel EW (2014b) Hearing loss, protection, and regeneration
in the larval zebrafi sh lateral line. In: Coombs S, Bleckmann H, Fay RR, Popper AN (eds) The
lateral line system. Springer, New York
Collins SP, Marshall JN, Atema J, Fay RR (2003) Sensory processing aquatic environments.
Springer, New York
Coombs S, Görner P, Münz H (1989) The mechanosensory lateral line: neurobiology and evolution. Springer-Verlag, New York
Coombs S, Braun CB, Donovan B (2001) The orienting response of Lake Michigan mottled sculpin is mediated by canal neuromasts. J Exp Biol 204:337–348
Coombs S, Bleckmann H, Fay RR, Popper AN (2014) The lateral line system. Springer, New York
Corwin JT, Oberholtzer JC (1997) Fish n’ chicks: model recipes for hair-cell regeneration? Neuron
19(5):951–954
Cunningham LL, Cheng AG, Rubel EW (2002) Caspase activation in hair cells of the mouse utricle exposed to neomycin. J Neurosci 22(19):8532–8540
Chemical Ototoxicity of the Fish Inner Ear and Lateral Line
Behra M, Bradsher J, Sougrat R, Gallardo V, Allende ML, Burgess SM (2009) Phoenix is required
for mechanosensory hair cell regeneration in the zebrafi sh lateral line. PLoS Genet 5(4),
e1000455
Bhandiwad AA, Zeddies DG, Raible DW, Rubel EW, Sisneros JA (2013) Auditory sensitivity of
larval zebrafi sh ( Danio rerio ) measured using a behavioral prepulse inhibition assay. J Exp Biol
216(18):3504–3513
Blechinger SR, Kusch RC, Haugo K, Matz C, Chivers DP, Krone PH (2007) Brief embryonic
cadmium exposure induces a stress response and cell death in the developing olfactory system
followed by long-term olfactory defi cits in juvenile brafi sh. Toxicol Appl Pharmacol
224(1):72–80
Bleckmann H, Zelick R (2009) Lateral line system of fi sh. Integr Zool 4(1):13–25
Brack CL, Ramcharitar J (2012) Assessment of lateral line function: a potential technique for studies on ototoxicity. J Clin Neurosci 19:333–335
Braun CB, Coombs S (2000) The overlapping role of the inner ear and lateral line: the active space
of dipole source detection. Philos Trans R Soc Lond 355:1115–1119
Brignull HR, Raible DW, Stone JS (2009) Feathers and fi ns: non-mammalian models for hair cell
regeneration. Brain Res 1277:12–23
Brown AD, Mussen TD, Sisneros JA, Coffi n AB (2011) Reevaluating the use of aminoglycoside
antibiotics in behavioral studies of the lateral line. Hear Res 272(1–2):1–4
Buck LMJ, Winter MJ, Redfern WS, Whitfi eld TT (2012) Ototoxin-induced cellular damage in
neuromasts disrupts lateral line function in larval zebrafi sh. Hear Res 284:67–81
Chang JSY, Popper AN, Saidel WM (1992) Heterogeneity of sensory hair cells in a fi sh ear.
J Comp Neurol 324:621–640
Cheng AG, Cunningham LL, Rubel EW (2005) Mechanisms of hair cell death and protection. Curr
Opin Otolaryngol Head Neck Surg 13(6):343–348
Chiu LL, Cunningham LL, Raible DW, Rubel EW, Ou HC (2008) Using the zebrafi sh lateral line
to screen for ototoxicity. J Assoc Res Otolaryngol 9(2):178–190
Coffi n AB, Kelley MW, Manley GA, Popper AN (2004) Evolution of sensory hair cells. In: Manley
GA, Fay RR, Popper AN (eds) Evolution of the auditory system. Springer-Verlag, New York
Coffi n AB, Ou H, Owens KN, Santos F, Simon JA, Rubel EW, Raible DW (2010) Chemical
screening for hair cell loss and protection in the zebrafi sh lateral line. Zebrafi sh 7(1):3–11
Coffi n AB, Rubel EW, Raible DW (2013a) Bax, Bcl2, and p53 differentially regulate neomycinand gentamicin-induced hair cell death in the zebrafi sh lateral line. J Assoc Res Otolaryngol.
doi: 10.1007/s10162-013-0404-1
Coffi n AB, Williamson KL, Mamiya A, Raible DW, Rubel EW (2013b) Profi ling drug-induced cell
death pathways in the zebrafi sh lateral line. Apoptosis. doi: 10.1007/s10495-013-0816-8
Coffi n AB, Zeddies DG, Fay RR, Brown AD, Alderks PW, Bhandiwad AA, Mohr RA, Gray MD,
Rogers PH, Sisneros JA (2014a) Use of the swim bladder and lateral line in near-fi eld sound
source localization by fi shes. J Exp Biol. doi: 10.1242/jeb.093831
Coffi n AB, Brignull H, Raible DW, Rubel EW (2014b) Hearing loss, protection, and regeneration
in the larval zebrafi sh lateral line. In: Coombs S, Bleckmann H, Fay RR, Popper AN (eds) The
lateral line system. Springer, New York
Collins SP, Marshall JN, Atema J, Fay RR (2003) Sensory processing aquatic environments.
Springer, New York
Coombs S, Görner P, Münz H (1989) The mechanosensory lateral line: neurobiology and evolution. Springer-Verlag, New York
Coombs S, Braun CB, Donovan B (2001) The orienting response of Lake Michigan mottled sculpin is mediated by canal neuromasts. J Exp Biol 204:337–348
Coombs S, Bleckmann H, Fay RR, Popper AN (2014) The lateral line system. Springer, New York
Corwin JT, Oberholtzer JC (1997) Fish n’ chicks: model recipes for hair-cell regeneration? Neuron
19(5):951–954
Cunningham LL, Cheng AG, Rubel EW (2002) Caspase activation in hair cells of the mouse utricle exposed to neomycin. J Neurosci 22(19):8532–8540
Chemical Ototoxicity of the Fish Inner Ear and Lateral Line