4.6
Artifacts
Many factors can affect the outcome of histological sections or
its image capture when slides are viewed under light microscopy. Inadequate fixation, processing or staining, low-quality
optics and improper adjustment of the microscope illumination are a few examples of interfering factors. In general,
artefacts represent changes that were not originally present in
the living tissue. These changes are accidentally or artificially
produced at any of the steps from the tissue sampling,
processing, to section interpretation, and it is important that
Fig. 4.31 (continued)
50
4 Pathology and Disease Diagnosis
Artifacts
Many factors can affect the outcome of histological sections or
its image capture when slides are viewed under light microscopy. Inadequate fixation, processing or staining, low-quality
optics and improper adjustment of the microscope illumination are a few examples of interfering factors. In general,
artefacts represent changes that were not originally present in
the living tissue. These changes are accidentally or artificially
produced at any of the steps from the tissue sampling,
processing, to section interpretation, and it is important that
Fig. 4.31 (continued)
50
4 Pathology and Disease Diagnosis