222
M.A. Masini et al.
Concluding Remarks
Atrial natriuretic peptides are generally considered to be regulators of body
fluid volume and electrolyte balance, and to control hemodynamics in
vertebrates. Studies on natriuretic peptides from the eel indicate that they
play a role in the adaptations to different enviromental salinities and
cardiovascular activity. Antarctic teleosts are very specialized fishes and
atrial natriuretic peptides may be essential for their survival in their extreme
environment. Further work is necessary to characterize the molecular
sequence of the peptides, and the affinity and structure of the receptor
subtypes. The administration of homologous ANPs may clarify the
physiological role played by this family of peptides in the different
environmental and hemodynamic conditions encountered by the Antarctic
teleosts.
Acknowledgments
This research has been supported by the Italian Programme for Antarctic Research
(PNRA).
References
1. Takei Y (1992) Vasoactive hormones and body fluid homeostasis: a
phylogenetic consideration. In: Kuwasawa K, Hill RB, McMahon BR, T
Kuramoto (eds) Comparative physiology, vol 11. Karger Flynn, Basel, pp
239-249
2. DeBold ML, DeBold AJ (1983) The amino acid sequence of an atrial peptide
with potent diuretic and natriuretic properties. Biochem Biophys Res
Commun 117:859-865
3. Currie MG, Geller DM, Cole BR, Siegel NR, Fok KS, Adams SP, Eubanks
SR, Galluppi GR, Needleman P (1984) Purification and sequence analysis of
bioactive atrial peptides (atriopeptins). Science 223: 67-69
4. Cantin M, Genest J (1985) The heart and the atrial natriuretic factor.
Endocrinol Rev 6: 107-127
5. Goetz KL (1988) Physiology and pathophysiology of atrial peptides. Am. J
PhysioI254:EI-EI5
6. Gray DA, Schatz H, Gerstberger R (1991) Interaction of Atrial Natriuretic
Factor and osmoregulatory hormones in the Peking duck. Gen Comp
EndocrinoI81,246-255
7. Chapeau C, Gutkowska J, Sciller PW, Milne RW, Thibault G, Garcia R,
Genest J, Cantin M (1985) Localization of immunoreactve synthetic atrial
natriuretic factor (ANF) in the heart of various animal species. J Histoch
Cytochem 33:541-550
M.A. Masini et al.
Concluding Remarks
Atrial natriuretic peptides are generally considered to be regulators of body
fluid volume and electrolyte balance, and to control hemodynamics in
vertebrates. Studies on natriuretic peptides from the eel indicate that they
play a role in the adaptations to different enviromental salinities and
cardiovascular activity. Antarctic teleosts are very specialized fishes and
atrial natriuretic peptides may be essential for their survival in their extreme
environment. Further work is necessary to characterize the molecular
sequence of the peptides, and the affinity and structure of the receptor
subtypes. The administration of homologous ANPs may clarify the
physiological role played by this family of peptides in the different
environmental and hemodynamic conditions encountered by the Antarctic
teleosts.
Acknowledgments
This research has been supported by the Italian Programme for Antarctic Research
(PNRA).
References
1. Takei Y (1992) Vasoactive hormones and body fluid homeostasis: a
phylogenetic consideration. In: Kuwasawa K, Hill RB, McMahon BR, T
Kuramoto (eds) Comparative physiology, vol 11. Karger Flynn, Basel, pp
239-249
2. DeBold ML, DeBold AJ (1983) The amino acid sequence of an atrial peptide
with potent diuretic and natriuretic properties. Biochem Biophys Res
Commun 117:859-865
3. Currie MG, Geller DM, Cole BR, Siegel NR, Fok KS, Adams SP, Eubanks
SR, Galluppi GR, Needleman P (1984) Purification and sequence analysis of
bioactive atrial peptides (atriopeptins). Science 223: 67-69
4. Cantin M, Genest J (1985) The heart and the atrial natriuretic factor.
Endocrinol Rev 6: 107-127
5. Goetz KL (1988) Physiology and pathophysiology of atrial peptides. Am. J
PhysioI254:EI-EI5
6. Gray DA, Schatz H, Gerstberger R (1991) Interaction of Atrial Natriuretic
Factor and osmoregulatory hormones in the Peking duck. Gen Comp
EndocrinoI81,246-255
7. Chapeau C, Gutkowska J, Sciller PW, Milne RW, Thibault G, Garcia R,
Genest J, Cantin M (1985) Localization of immunoreactve synthetic atrial
natriuretic factor (ANF) in the heart of various animal species. J Histoch
Cytochem 33:541-550