Metallothionein in Antarctic Fish
161
18. Schwarz MA, Lazo JS, Yalowich JC, Allen WP, Whitmore M, Bergonia HA,
Tzeng E, Billiar TR, Robbins PD, Lancaster J, Jr (1995) Metallothionein
protects against the cytotoxic and DNA-damaging effects of nitric oxide.
Proc Natl Acad Sci USA 92:4452-4456
19. Dalton T, Palmiter RD, Andrews GK (1994) Transcriptional induction ofthe
mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells
involves a composite major late transcription factor/antioxidant response
element and metal response promoter elements. Nucleic Acids Res 22:50165023
20. Xie T, Belinsky M, Xu Y, Jaiswal AK (1995) ARE- and TRE-mediated
regulation of gene expression. Response to xenobiotics and antioxidants. J
BioI Chern 270:6894-6900
21. Lazo JS, Kondo Y, Dellapiazza D, Michalska AE, Choo KH, Pitt BR (1995)
Enhanced sensitivity to oxidative stress in cultured embryonic cells from
transgenic mice deficient in metallothionein I and II genes. J BioI Chern
270:5506-5510
22. Kille P, Stephens PE, Kay J (1991) Elucidation of cDNA sequences for
metallothioneins from rainbow trout, stone loach and pike liver using the
polymemse chain reaction. Biochim Biophys Acta 1089:407-410
23. Peitsch MC (1996) Promod and Swiss model, internet-bond tools for
automated comparative protein modelling. Biochem Soc Trans 24:274-279
24. Scudiero R, De Prisco PP, Camardella L, D'Avino R, di Prisco G, Parisi E
(1992) Apparent deficiency of metallothionein in the liver of the Antarctic
ice fish Chionodraco hamatus. Identification and isolation of a zinccontaining protein unlike metallothionein. Comp Biochem Physiol 103B:201207
25. Scudiero R, Carginale V, Riggio M, Capasso C, Capasso A, Kille P, di Prisco
G, Parisi E (1997) Difference in hepatic metallothionein content in Antarctic
red-blooded and haemoglobinless fish: undetectable metallothionein levels in
haemoglobinless fish is accompained by accumulation of untranslated
metallothionein mRNA. Biochem J 322:207-211
161
18. Schwarz MA, Lazo JS, Yalowich JC, Allen WP, Whitmore M, Bergonia HA,
Tzeng E, Billiar TR, Robbins PD, Lancaster J, Jr (1995) Metallothionein
protects against the cytotoxic and DNA-damaging effects of nitric oxide.
Proc Natl Acad Sci USA 92:4452-4456
19. Dalton T, Palmiter RD, Andrews GK (1994) Transcriptional induction ofthe
mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells
involves a composite major late transcription factor/antioxidant response
element and metal response promoter elements. Nucleic Acids Res 22:50165023
20. Xie T, Belinsky M, Xu Y, Jaiswal AK (1995) ARE- and TRE-mediated
regulation of gene expression. Response to xenobiotics and antioxidants. J
BioI Chern 270:6894-6900
21. Lazo JS, Kondo Y, Dellapiazza D, Michalska AE, Choo KH, Pitt BR (1995)
Enhanced sensitivity to oxidative stress in cultured embryonic cells from
transgenic mice deficient in metallothionein I and II genes. J BioI Chern
270:5506-5510
22. Kille P, Stephens PE, Kay J (1991) Elucidation of cDNA sequences for
metallothioneins from rainbow trout, stone loach and pike liver using the
polymemse chain reaction. Biochim Biophys Acta 1089:407-410
23. Peitsch MC (1996) Promod and Swiss model, internet-bond tools for
automated comparative protein modelling. Biochem Soc Trans 24:274-279
24. Scudiero R, De Prisco PP, Camardella L, D'Avino R, di Prisco G, Parisi E
(1992) Apparent deficiency of metallothionein in the liver of the Antarctic
ice fish Chionodraco hamatus. Identification and isolation of a zinccontaining protein unlike metallothionein. Comp Biochem Physiol 103B:201207
25. Scudiero R, Carginale V, Riggio M, Capasso C, Capasso A, Kille P, di Prisco
G, Parisi E (1997) Difference in hepatic metallothionein content in Antarctic
red-blooded and haemoglobinless fish: undetectable metallothionein levels in
haemoglobinless fish is accompained by accumulation of untranslated
metallothionein mRNA. Biochem J 322:207-211