298
J. Querellou et al.
Table 8.3
(continued)
Authors
Origin of
sample(s)
Screening
method
Main targets
Industry
Reference
Biotechnology
Schirmer et al.
(2005)
Fieseler et al.
(2007)
Chu et al. (2008)
Sponge
Discodermia
20 sponge
species
Surface seawater,
China
Sequenced/PCR
Sequenced/PCR
Function based
Polyketide synthases (PKS)
Identification of pharma relevant
PKS genes
Lipases, esterases
Kosan a
Kosan
?
Short et al.
(1997)
Short (1999)
Weiner et al.
(2007)
Lee et al. (2008)
Diverse incl.
plankton
Whale bone,
picoplankton
Pacific Ocean
picoplankton
Deep-sea
sediment
Function based
Function based
Function based
Function based
Hydrolases (notably
thermostables)
Hydrolases
Oxidative enzymes (epoxidases,
P450) :
Fibrinolytic Metalloprotease
Diversa b
Diversa
Diversa
Patent
WO9704077
US5958672
US2007231820
WO2008056840
Robertson et al.
(2004)
Bertram et al.
(2008)
>600 biotopes
Information
missing
Function based
Function based
Nitrilases (137 novel enzymes)
Lipases, esterases (350 novel
enzymes)
Diversa
Verenium
a
Kosan Biosciences is now a subsidiary of Bristol-Myers;
b
Diversa is currently a branch of Verenium. Patent data were compiled from the European Patent Office (http://ep.espacenet.com/). In August 2008, a
query with metagenome as keyword led to 8 entries, most of them dedicated to soil metagenomes and cow rumen.