148
F. Raible and P.R.H. Steinmetz
Fig. 5.2
Domain evolution. Scenario of Hedgehog domain evolution by domain shuffling, duplication and loss during the evolution of metazoans (based on
Adamska et al. 2007b, King et al. 2008, Matus et al. 2008, Snell et al. 2006). Schematics at roots depict protein and domain arrangements present in the
common ancestor. Schematics within terminal branches depict putative rearrangements not present in the ancestor (derived). Grey boxes highlight protein
orthologues present in extant organisms
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