Part F | 32.3
780 Part F Marine Derived Metabolites
HO
HO
HO
OH
239: R = OCH 3
240: R = OCOCH 3
241: R = OH
252: R 1 , R 2 = H
253: R 1 = OH, R 2 = H
254: R 1 = OH, R 2 = CH 3
256: R 1 = H, R 2 = CHO
257: R 1 = CH 3 , R 2 = CHO
245: R = α–OCH 3
246: R = –OCH 3
231
255
249
250
251
258
259
260
232
242
243
244
247
248
233
234
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
N
N
N
N
N
O
O
O
N
H
H
N
N
H
O
O
O
O
O
O
N
N
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
R
O
O
O
O
O
O
O
R
R
R
O
O
O
O
O
O
O
O
O
O
O
O
O
O
OH
HO
HO
OH
HN
HN
HN
NH
HN
O
O
O
O
O
N
N
N
N
N
O
O
O
O
O S
O
O
N
N
H
N
H
H
N
HN
NH
Me-Ala
4
Me-Ala
2
Ala
1
R 1
R 2
Abz
5
Val-1
Val-4
Ala-3
Hyppa-5
PKS
NRPS
Ile-2
Abz
3
O
O
O
O
O
N
N
N
O
O
O
N
O
O
O
O
H
N
N
HN
HN
OH
OH
OH
NH
Ala
4
Me-Ala
2
Me-Ala
1
Abz
5
Abz
3
HO
HO
R 2
R 1
HO
235
O
O
O
O
236
237
238
O
O
O
H
O
O
O
O
O
O
HO
HO
OH
OH
OH
OH
OH
OH
NH
HN
NH
OH
OH
OH
OH
O
Fig. 32.12 Chemical structures of compounds 231–260
derivatives (234–238) were obtained from a culture
extract of Aspergillus wentii EN-48, an endophytic fungus isolated from an unidentified marine brown algal
species of the genus Sargassum [32.145]. The absolute
configurations of asperolide A (231) and wentilactone
(236) were established based on X-ray crystallographic
analysis [32.145]. All isolated compounds were assessed for their cytotoxic activities against seven differ-