Part F | 32.3
776 Part F Marine Derived Metabolites
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
OH
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
HO
Cl
OH
HO
HO
HO
HO
156: 19R
157: 19S
158: R = OCH 3
159: R = OCH 2 CH 3
161: R = CH 3
162: R = CH 2 OH
173: R = H
174: R = COOH
185: R = CH 3
186: R = H
175: R 1 = CH 2 OH, R 2 = H
176: R 1 = CH 2 OH, R 2 = OH
177: R 1 = COOH, R 2 = OH
163: R 1 , R 2 = H
164: R 1 = OH, R 2 = H
165: R 1 = H, R 2 = OH
160
155
166
178
179
182
183
184
171
170
172
180
181
167
168
169
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
R
R 1
R 2
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
R
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
O
R
R 1
R 2
O
R
19
Fig. 32.10 Chemical structures of compounds 155–186
be due to the diketo-lactone ring [32.131]. Moreover, in
the agar diffusion assay against Mycobacterium phlei,
considerable inhibition zones were observed for compounds 164, 166, and 169, whereas 163 and 167 showed
potent cytotoxic effects toward human leukocyte elastase (HLE) with IC 50 values of 7:2 and 13:3 M,
respectively [32.131].
Five new polyketides, xestodecalactones D–F (170–
172), corynesidone C (173), and 6-(3
0 -hydroxybutyl)7-O-methylspinochrome B (186), were isolated from