Contents XXIII
27 Marine Actinomycetes in Biodiscovery
D. İpek Kurtböke, Tanja Grkovic, Ronald J. Quinn ............................
663
27.1 Overview .................................................................
663
27.2 Advances in the Field of Biodiscovery: Genomics and Genome
Mining for Discovery of New Antibiotics ...............................
665
27.3 Ecological and Physiological Perspectives .............................
666
27.4 An Australian Example: Exploring the Biosynthetic Potential
of a Marine-Derived Streptomycete....................................
668
27.5 Future Prospects .........................................................
671
References .......................................................................
672
28 Biotransformation of Nitriles by Marine Fungi
Julieta Rangel de Oliveira, Mirna H. Reagli Seleghim,
André L. Meleiro Porto ..........................................................
677
28.1 Overview .................................................................
678
28.2 Experimental Methods ..................................................
691
28.3 Results and Discussion ..................................................
696
28.4 Conclusion ...............................................................
705
References .......................................................................
706
Part F Marine Derived Metabolites
29 Drugs and Leads from the Ocean Through Biotechnology
José de Jesús Paniagua-Michel, Jorge Olmos-Soto,
Eduardo Morales-Guerrero .....................................................
711
29.1 Overview and Current Status ...........................................
712
29.2 Approved Marine Drugs as Pharmaceuticals ..........................
713
29.3 Marine Natural Products – Overcoming Hurdles ......................
718
29.4 Quo Vadis? Marine Natural Products and Clinical Trials ..............
718
29.5 Marine Natural Products: New and Recurrent Challenges ...........
720
References .......................................................................
724
30 Biocatalysts from Aplysia: Sweet Spot in Enzymatic Carbohydrate
Synthesis
Antonio Trincone ................................................................
731
30.1 Biocatalysis, Glycosylation and Marine Enzymes .....................
731
30.2 Biocatalytic Methodologies to Access Glycosides
and Oligosaccharides ...................................................
732
30.3 The Marine Ecosystem as a Source for New Glycoside Hydrolases ...
734
30.4 Glycoside Hydrolases Present in the Genus Aplysia ..................
735
30.5 Other Enzymatic Activities of Interest Present in Aplysia sp. ........
741
30.6 Conclusion ...............................................................
742
References .......................................................................
742
31 Antimicrobial Peptides from Marine Organisms
Venugopal Rajanbabu, Jyh-Yih Chen, Jen-Leih Wu ..........................
747
31.1 Marine Antimicrobial Peptides .........................................
747
31.2 Isolation of Antimicrobial Peptides ....................................
748