206
A. Vortkamp
dral bone development by directly controlling chondrocyte differentiation.
Proc Natl Acad Sci USA 95:13030-13035
Duprez D, Bell EJ, Richardson MK, Archer CW, Wolpert L, Brickell PM,
Francis-West PH (1996) Overexpression of BMP-2 and BMP-4 alters the
size and shape of developing skeletal elements in the chick limb. Mech Dev
57:145-157
Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R (1995) Toward a molecular understanding of skeletal development. Cell 80:371-378
Floyd WED, Zaleske DJ, Schiller AL, Trahan C, Mankin HJ (1987) Vascular
events associated with the appearance of the secondary center of ossification in the murine distal femoral epiphysis. J Bone Joint Surg Am
69:185-190
Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP (1996)
Conservation of the hedgehog/patched signaling pathway from flies to
mice: induction of a mouse patched gene by hedgehog. Genes Dev
10:301-312
Hamburger V, Hamilton HL (1951) A series of normal stages in the development of the chick embryo. J Exp Morph 88:49-92
Hinchcliffe JR, Johnson DR (1980) The development of the Vertebrate limb,
Oxford University Press, New York
Hirsinger E, Duprez D, Jouve C, Malapert P, Cooke J, Pourquie 0 (1997) Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in
avian somite patterning. Development 124:4605-4614
Hogan BLM (1996) Bone morphogenetic proteins: multifunctional regulators
of vertebrate development. Genes Dev 10:1580-1594
Iwasaki M, Le AX, Helms JA (1997) Expression of Indian hedgehog, bone
morphogenetic protein 6 and gli during skeletal morphogenesis. Mech Dev
69:197-202
Jones CM, Lyons KM, Hogan BL (1991) Involvement of Bone Morphogenetic
Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the
mouse. Development 111 :531-542
Juppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J,
Kolakowski L Jr, Hock J, Potts J Jr, Kronenberg HM (1991) A G proteinlinked receptor for parathyroid hormone and parathyroid hormone-related
peptide. Science 254: 1024-1026
Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg
HM, Mulligan RC (1994) Lethal skeletal dysplasia from targeted disruption
of the parathyroid hormone-related peptide gene. Genes Dev 8:277-289
Kawakami Y, Ishikawa T, Shimabara M, Tanda N, Enomoto-Iwamoto M,
Iwamoto M, Kuwana T, Ueki A, Noji S, Nohno T (1996) BMP signaling
during bone pattern determination in the developing limb. Development
122:3557-3566
A. Vortkamp
dral bone development by directly controlling chondrocyte differentiation.
Proc Natl Acad Sci USA 95:13030-13035
Duprez D, Bell EJ, Richardson MK, Archer CW, Wolpert L, Brickell PM,
Francis-West PH (1996) Overexpression of BMP-2 and BMP-4 alters the
size and shape of developing skeletal elements in the chick limb. Mech Dev
57:145-157
Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R (1995) Toward a molecular understanding of skeletal development. Cell 80:371-378
Floyd WED, Zaleske DJ, Schiller AL, Trahan C, Mankin HJ (1987) Vascular
events associated with the appearance of the secondary center of ossification in the murine distal femoral epiphysis. J Bone Joint Surg Am
69:185-190
Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP (1996)
Conservation of the hedgehog/patched signaling pathway from flies to
mice: induction of a mouse patched gene by hedgehog. Genes Dev
10:301-312
Hamburger V, Hamilton HL (1951) A series of normal stages in the development of the chick embryo. J Exp Morph 88:49-92
Hinchcliffe JR, Johnson DR (1980) The development of the Vertebrate limb,
Oxford University Press, New York
Hirsinger E, Duprez D, Jouve C, Malapert P, Cooke J, Pourquie 0 (1997) Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in
avian somite patterning. Development 124:4605-4614
Hogan BLM (1996) Bone morphogenetic proteins: multifunctional regulators
of vertebrate development. Genes Dev 10:1580-1594
Iwasaki M, Le AX, Helms JA (1997) Expression of Indian hedgehog, bone
morphogenetic protein 6 and gli during skeletal morphogenesis. Mech Dev
69:197-202
Jones CM, Lyons KM, Hogan BL (1991) Involvement of Bone Morphogenetic
Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the
mouse. Development 111 :531-542
Juppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J,
Kolakowski L Jr, Hock J, Potts J Jr, Kronenberg HM (1991) A G proteinlinked receptor for parathyroid hormone and parathyroid hormone-related
peptide. Science 254: 1024-1026
Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg
HM, Mulligan RC (1994) Lethal skeletal dysplasia from targeted disruption
of the parathyroid hormone-related peptide gene. Genes Dev 8:277-289
Kawakami Y, Ishikawa T, Shimabara M, Tanda N, Enomoto-Iwamoto M,
Iwamoto M, Kuwana T, Ueki A, Noji S, Nohno T (1996) BMP signaling
during bone pattern determination in the developing limb. Development
122:3557-3566