82
K. M. G. Mostofa et al.
Table 3 Analyte-dependent mass spectrometry parameters for target compounds (data source Ramirez et al. 2007; RxList (The Internet Drug Index) 2005)
Compound
Use
Structure
Precursor ion
Collision energy (eV) Product ion pKa a
ESI positive analytes
Acetaminophen
Analgesic
152 [M
+ H]
+
−11.0
110
9.86
Atenolol
Anti-hypertension
267 [M
+ H|
+
−21.5
145
9.16
Cimetidine
Anti-acid reflux
253 [M
+ H]
+
−13.5
159
7.07
Codeine
Analgesic
300 [M
+ Η] +
−38.0
215
8.25
1,7-dimethylxanthine
Caffeine
metabolite
181 [M
+ H]
+
−15.5
124
8.50
Liltcomycin
Antibiotic
407 [Μ
+ H]
+
−15.5
359
8.78
(continued)