73
Smith RA, Dupe RJ, English PD, Green J (1981) Fibrinolysis with acyl-enzymes: a new approach
to thrombolytic therapy. Nature 290:505–508
Stalmans P, Benz MS, Gandorfer A, Kampik A, Girach A, Pakola S, Haller JA (2012) Enzymatic
Vitreolysis with ocriplasmin for vitreomacular traction and macular holes. N Engl J Med
367:606–615
Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H (1987) A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese natto; a typical and popular soybean food in the Japanese diet.
Experientia 43:1110–1111
Van Hove JL, Yang HW, Wu JY, Brady RO, Chen YT (1996) High-level production of recombinant
human lysosomal acid alpha-glucosidase in Chinese hamster ovary cells which targets to heart
muscle and corrects glycogen accumulation in fibroblasts from patients with pompe disease.
Proceedings of the National Academy Sciences of United States of America 93:65–70
White MJV, Glenn M, Gomer RH (2013) Trypsin potentiates human fibrocyte differentiation.
PLoS One 8:e70795
Zamarron C, Lijnen HR, Van Hoef B, Collen D (1984) Biological and thrombolytic properties of
proenzyme and active forms of human urokinase--I. Fibrinolytic and fibrinogenolytic properties in human plasma in vitro of urokinases obtained from human urine or by recombinant
DNA technology. Thromb Haemost 52:19–23
Zimran A, Brill-Almon E, Chertkoff R, Petakov M, Blanco-Favela F, Muñoz ET, Solorio-Meza
SE, Amato D, Duran G, Giona F, Heitner R, Rosenbaum H, Giraldo P, Mehta A, Park G,
Phillips M, Elstein D, Altarescu G, Szleifer M, Hashmueli S, Aviezer D (2011) Pivotal trial
with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme
replacement therapy for gaucher disease. Blood 118:5767–5773
2 Therapeutic Enzymes
Smith RA, Dupe RJ, English PD, Green J (1981) Fibrinolysis with acyl-enzymes: a new approach
to thrombolytic therapy. Nature 290:505–508
Stalmans P, Benz MS, Gandorfer A, Kampik A, Girach A, Pakola S, Haller JA (2012) Enzymatic
Vitreolysis with ocriplasmin for vitreomacular traction and macular holes. N Engl J Med
367:606–615
Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H (1987) A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese natto; a typical and popular soybean food in the Japanese diet.
Experientia 43:1110–1111
Van Hove JL, Yang HW, Wu JY, Brady RO, Chen YT (1996) High-level production of recombinant
human lysosomal acid alpha-glucosidase in Chinese hamster ovary cells which targets to heart
muscle and corrects glycogen accumulation in fibroblasts from patients with pompe disease.
Proceedings of the National Academy Sciences of United States of America 93:65–70
White MJV, Glenn M, Gomer RH (2013) Trypsin potentiates human fibrocyte differentiation.
PLoS One 8:e70795
Zamarron C, Lijnen HR, Van Hoef B, Collen D (1984) Biological and thrombolytic properties of
proenzyme and active forms of human urokinase--I. Fibrinolytic and fibrinogenolytic properties in human plasma in vitro of urokinases obtained from human urine or by recombinant
DNA technology. Thromb Haemost 52:19–23
Zimran A, Brill-Almon E, Chertkoff R, Petakov M, Blanco-Favela F, Muñoz ET, Solorio-Meza
SE, Amato D, Duran G, Giona F, Heitner R, Rosenbaum H, Giraldo P, Mehta A, Park G,
Phillips M, Elstein D, Altarescu G, Szleifer M, Hashmueli S, Aviezer D (2011) Pivotal trial
with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme
replacement therapy for gaucher disease. Blood 118:5767–5773
2 Therapeutic Enzymes