438
Tang J, Maddali K, Dreis CD, Sham YY, Vince R, Pommier Y, Wang Z (2011) N-3 hydroxylation
of pyrimidine-2,4-diones yields dual inhibitors of HIV reverse transcriptase and integrase. ACS
Med Chem Lett 2(1):63–67
Tremblay M, Bonneau P, Bousquet Y, DeRoy P, Duan J, Duplessis M, Gagnon A, Garneau M,
Goudreau N, Guse I, Hucke O, Kawai SH, Lemke CT, Mason SW, Simoneau B, Surprenant S,
Titolo S, Yoakim C (2012) Inhibition of HIV-1 capsid assembly: optimization of the antiviral
potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)1H-benzimidazole scaffold. Bioorg Med Chem Lett 22(24):7512–7517
UNAIDS (2016) Global AIDS update, 2016. Retrieved June 29, 2016, from http://www.unaids.
org/en/resources/documents/2016/Global-AIDS-update-2016
Velthuisen EJ, Johns BA, Temelkoff DP, Brown KW, Danehower SC (2016) The design of
8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors. Eur J Med
Chem 117:99–112
Wan Z, Yao J, Mao T, Wang X, Wang H, Chen W, Yin H, Chen FE, De Clercq E, Daelemans D,
Pannecouque C (2015) Pyrimidine sulfonylacetanilides with improved potency against key
mutant viruses of HIV-1 by specific targeting of a highly conserved residue. Eur J Med Chem
102:215–222
Wang S, Huber PW, Cui M, Czarnik AW, Mei H (1998) Binding of neomycin to the TAR element
of HIV-1 RNA induces dissociation of tat protein by an allosteric mechanism. Biochemistry
37(16):5549–5557
Wannberg J, Sabnis YA, Vrang L, Samuelsson B, Karlén A, Hallberg A, Larhed M (2006) A new
structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-substituted P1/P1′ side
chains. Bioorg Med Chem 14(15):5303–5315
Wu B, Tang J, Wilson DJ, Huber AD, Casey MC, Ji J, Kankanala J, Xie J, Sarafianos SG, Wang Z
(2016) 3-hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides potently inhibit HIV-1 integrase and RNase H. J Med Chem 59(13):6136–6148
Yang J, Chen W, Kang D, Lu X, Li X, Liu Z et al (2016) Design, synthesis and anti-HIV evaluation
of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket.
Eur J Med Chem 109:294–304
Zhan P, Pannecouque C, De Clercq E, Liu X (2016) Anti-HIV drug discovery and development:
current innovations and future trends. J Med Chem 59(7):2849–2878
Zhao XZ, Smith SJ, Maskell DP, Metifiot M, Pye VE, Fesen K et al (2016) HIV-1 integrase strand
transfer inhibitors with reduced susceptibility to drug resistant mutant integrases. ACS Chem
Biol 11(4):1074–1081
N. Ranjan et al.
Tang J, Maddali K, Dreis CD, Sham YY, Vince R, Pommier Y, Wang Z (2011) N-3 hydroxylation
of pyrimidine-2,4-diones yields dual inhibitors of HIV reverse transcriptase and integrase. ACS
Med Chem Lett 2(1):63–67
Tremblay M, Bonneau P, Bousquet Y, DeRoy P, Duan J, Duplessis M, Gagnon A, Garneau M,
Goudreau N, Guse I, Hucke O, Kawai SH, Lemke CT, Mason SW, Simoneau B, Surprenant S,
Titolo S, Yoakim C (2012) Inhibition of HIV-1 capsid assembly: optimization of the antiviral
potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)1H-benzimidazole scaffold. Bioorg Med Chem Lett 22(24):7512–7517
UNAIDS (2016) Global AIDS update, 2016. Retrieved June 29, 2016, from http://www.unaids.
org/en/resources/documents/2016/Global-AIDS-update-2016
Velthuisen EJ, Johns BA, Temelkoff DP, Brown KW, Danehower SC (2016) The design of
8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors. Eur J Med
Chem 117:99–112
Wan Z, Yao J, Mao T, Wang X, Wang H, Chen W, Yin H, Chen FE, De Clercq E, Daelemans D,
Pannecouque C (2015) Pyrimidine sulfonylacetanilides with improved potency against key
mutant viruses of HIV-1 by specific targeting of a highly conserved residue. Eur J Med Chem
102:215–222
Wang S, Huber PW, Cui M, Czarnik AW, Mei H (1998) Binding of neomycin to the TAR element
of HIV-1 RNA induces dissociation of tat protein by an allosteric mechanism. Biochemistry
37(16):5549–5557
Wannberg J, Sabnis YA, Vrang L, Samuelsson B, Karlén A, Hallberg A, Larhed M (2006) A new
structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-substituted P1/P1′ side
chains. Bioorg Med Chem 14(15):5303–5315
Wu B, Tang J, Wilson DJ, Huber AD, Casey MC, Ji J, Kankanala J, Xie J, Sarafianos SG, Wang Z
(2016) 3-hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides potently inhibit HIV-1 integrase and RNase H. J Med Chem 59(13):6136–6148
Yang J, Chen W, Kang D, Lu X, Li X, Liu Z et al (2016) Design, synthesis and anti-HIV evaluation
of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket.
Eur J Med Chem 109:294–304
Zhan P, Pannecouque C, De Clercq E, Liu X (2016) Anti-HIV drug discovery and development:
current innovations and future trends. J Med Chem 59(7):2849–2878
Zhao XZ, Smith SJ, Maskell DP, Metifiot M, Pye VE, Fesen K et al (2016) HIV-1 integrase strand
transfer inhibitors with reduced susceptibility to drug resistant mutant integrases. ACS Chem
Biol 11(4):1074–1081
N. Ranjan et al.
Précédent