425
Protease
inhibitors
Ritonavir
Enzyme active site binding
Diarrhea, nausea, vomiting
March 1, 1996
Protease
inhibitors
Indinavir
Enzyme active site binding
Diarrhea, nausea, vomiting
March 13, 1996
Protease
inhibitors
Nelfinavir
Enzyme binding
Flatulence, diarrhea, rash
March 14, 1997
Protease
inhibitors
Atazanavir
Enzyme binding
Headache, nausea, rash, vomiting
June 20, 2003
Protease
inhibitors
Fosamprenavir
Enzyme active site binding
Diarrhea, dizziness
October 20, 2003
Protease
inhibitors
Tipranavir
Enzyme active site binding
Intracranial hemorrhage,
hyperglycemia
June 22, 2005
Protease
inhibitors
Darunavir
Enzyme active site binding
Diarrhea, headache, abdominal pain
June 23, 2006
Pharmacokinetic
enhancers
Cobicistat
Inhibit functions of liver enzymes
Nausea, diarrhea, fatigue
September 24, 2014
a
Partly adapted from aidsinfo.nih.gov factsheet (Retrieved May 30, 2016)
b
Nucleotide reverse transcriptase (RT) inhibitors
c
Nucleotide triphosphate
d
Nonnucleotide reverse transcriptase (RT) inhibitors
18 Novel Targets and Advancements in Drug Discovery: The Case of HIV-AIDS