351
© Springer Nature Singapore Pte Ltd. 2017
S. Sugathan et al. (eds.), Bioresources and Bioprocess in Biotechnology,
DOI 10.1007/978-981-10-4284-3_14
G. Seghal Kiran (*) • A. Sajayan
Department of Food Science and Technology, Pondicherry University,
Puducherry 605014, India
e-mail: seghalkiran@gmail.com
S. Hassan • J. Selvin
Department of Microbiology, School of Life Sciences, Pondicherry University,
Puducherry 605014, India
14
Quorum Quenching Compounds
from Natural Sources
G. Seghal Kiran, Saqib Hassan, Arya Sajayan,
and Joseph Selvin
Abstract
Quorum sensing is a process of bacterial communication system wherein the
production and secretion of small signaling molecules known as autoinducers
enables the bacteria to express specific genes at particular population densities.
Quorum quenching (QQ) can be used as an alternative approach to regulate
pathogenicity. Well-established QQ strategies include amide bond hydrolysis,
lactone hydrolysis, paraoxonase enzymes, and QQ modification of acyl chain.
Plants in general lack advanced immune systems, and may have evolved to produce QQ compounds to combat with plant invading pathogens. Most common
sources of QQ compounds in marine environment are bacteria, fungi, algae,
bryozoan, corals, and sponges. Marine cyanobacteria have become one among
the best source for obtaining biologically active and structurally unique QQ natural products. QQ compounds are being innovated as alternatives of antibiotics to
treat pathogenic infections. Marine ecosystem is a unique and unexplored hotspot
for the development of new derivatives of potential QQ compounds.
Keywords
Quorum Quenching • Biofilm • Motility • Virulence • Signalling molecules
© Springer Nature Singapore Pte Ltd. 2017
S. Sugathan et al. (eds.), Bioresources and Bioprocess in Biotechnology,
DOI 10.1007/978-981-10-4284-3_14
G. Seghal Kiran (*) • A. Sajayan
Department of Food Science and Technology, Pondicherry University,
Puducherry 605014, India
e-mail: seghalkiran@gmail.com
S. Hassan • J. Selvin
Department of Microbiology, School of Life Sciences, Pondicherry University,
Puducherry 605014, India
14
Quorum Quenching Compounds
from Natural Sources
G. Seghal Kiran, Saqib Hassan, Arya Sajayan,
and Joseph Selvin
Abstract
Quorum sensing is a process of bacterial communication system wherein the
production and secretion of small signaling molecules known as autoinducers
enables the bacteria to express specific genes at particular population densities.
Quorum quenching (QQ) can be used as an alternative approach to regulate
pathogenicity. Well-established QQ strategies include amide bond hydrolysis,
lactone hydrolysis, paraoxonase enzymes, and QQ modification of acyl chain.
Plants in general lack advanced immune systems, and may have evolved to produce QQ compounds to combat with plant invading pathogens. Most common
sources of QQ compounds in marine environment are bacteria, fungi, algae,
bryozoan, corals, and sponges. Marine cyanobacteria have become one among
the best source for obtaining biologically active and structurally unique QQ natural products. QQ compounds are being innovated as alternatives of antibiotics to
treat pathogenic infections. Marine ecosystem is a unique and unexplored hotspot
for the development of new derivatives of potential QQ compounds.
Keywords
Quorum Quenching • Biofilm • Motility • Virulence • Signalling molecules