322
produced by the genus Penicillium, including rugulosuvines, brevianamides and
fellutanine A–E; isofellutanine B and C are also reported to have antibiotic potentials. Viridicatin and Viridicatol are quinoline alkaloids produced by the Penicillium
fungi with antimicrobial activity against Mycobacterium tuberculosis. Quinocitrinins
are another group of secondary metabolites produced by the Penicillium group with
known activity against gram-positive and gram-negative bacteria, yeast and fungi.
O
O
O
OH
OH
O
O
H
N
N
N
NH
+
NH
NH
HN
O
O
O
O
HO
HO
OH
OH
OH
OH
OH
O
Cl
O
O
O
O
O
O
O
O
O
OH
H
H
H
OH
OH
O
CH 3
CH 3
CH 3
CH 3
H 3 C
H 3 C
H 3 C
H 3 C
H 3 C
CH 3
H 3 C
CH 3
CH 3
CH 3
N
HN
H
H
H
HO
HO
O
H
CH 3
H 3 C
CH 3
H 3 C
GRISEOFULVIN
STROBILURIN A
SORDARIN
ECHINOCANDIN B
AGROCLAVINE
TERRAIN
a
b
c
d
e
f
Fig. 12.9 Some antimicrobial compounds produced by fungi
D. Francis