235
© Springer Nature Singapore Pte Ltd. 2017
S. Sugathan et al. (eds.), Bioresources and Bioprocess in Biotechnology,
DOI 10.1007/978-981-10-4284-3_10
B.C. Bhavya • M. Haridas (*)
Inter University Centre for Bioscience, Department of Biotechnology and Microbiology,
Kannur University, Thalassery Campus, Kannur 6706661, Kerala, India
e-mail: mharidasm@rediffmail.com
10
Anti-inflammatory Molecules: Immune
System Mediators
B.C. Bhavya and Madathilkovilakath Haridas
Abstract
Inflammation typifies the chief defensive mechanism against infection or injury.
However, its obnoxious activation often elicits exaggerated immune response
and the onset of clinically relevant detrimental responses. Suppression of inflammatory response by means of anti-inflammatory molecules is therefore weighed
as a pivotal therapeutic solution to a wide range of diseases. The quest for newer
and vital anti-inflammatory molecules has been considered as an active research
vista for the development of potential drug candidates for a variety of pathological conditions. Inflammation and immune responses are inseparably linked in
many instances, where the persisting inflammatory response serves as the key
trigger for immune disorders. The immune system comprises immune cells and
immunoglobulins, which are the major mediators of defensive response against
obnoxious stimuli. Several anti-inflammatory molecules have been found to
ameliorate immune reaction underlying many pathogenesis, via directly regulating production/function/activation of the prime components of the immune system and limit tissue damage. This chapter provides an insight into the ability of
such anti-inflammatory molecules which target components of the immune system. The interplay of adaptive immunity and inflammatory mechanism in terms
of chronic inflammatory disease pathogenesis is critically evaluated and demonstrated. An effort has been made to explain how this approach of inhibiting
inflammatory targets qualifies as a potent therapeutic solution for immune disorders and transplant rejection. The emphasis is on identifying plausible antiinflammatory agents targeting immune system mediators as a logical strategy for
novel and efficient therapeutic interventions.
© Springer Nature Singapore Pte Ltd. 2017
S. Sugathan et al. (eds.), Bioresources and Bioprocess in Biotechnology,
DOI 10.1007/978-981-10-4284-3_10
B.C. Bhavya • M. Haridas (*)
Inter University Centre for Bioscience, Department of Biotechnology and Microbiology,
Kannur University, Thalassery Campus, Kannur 6706661, Kerala, India
e-mail: mharidasm@rediffmail.com
10
Anti-inflammatory Molecules: Immune
System Mediators
B.C. Bhavya and Madathilkovilakath Haridas
Abstract
Inflammation typifies the chief defensive mechanism against infection or injury.
However, its obnoxious activation often elicits exaggerated immune response
and the onset of clinically relevant detrimental responses. Suppression of inflammatory response by means of anti-inflammatory molecules is therefore weighed
as a pivotal therapeutic solution to a wide range of diseases. The quest for newer
and vital anti-inflammatory molecules has been considered as an active research
vista for the development of potential drug candidates for a variety of pathological conditions. Inflammation and immune responses are inseparably linked in
many instances, where the persisting inflammatory response serves as the key
trigger for immune disorders. The immune system comprises immune cells and
immunoglobulins, which are the major mediators of defensive response against
obnoxious stimuli. Several anti-inflammatory molecules have been found to
ameliorate immune reaction underlying many pathogenesis, via directly regulating production/function/activation of the prime components of the immune system and limit tissue damage. This chapter provides an insight into the ability of
such anti-inflammatory molecules which target components of the immune system. The interplay of adaptive immunity and inflammatory mechanism in terms
of chronic inflammatory disease pathogenesis is critically evaluated and demonstrated. An effort has been made to explain how this approach of inhibiting
inflammatory targets qualifies as a potent therapeutic solution for immune disorders and transplant rejection. The emphasis is on identifying plausible antiinflammatory agents targeting immune system mediators as a logical strategy for
novel and efficient therapeutic interventions.