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amino acids as serine and proline. This pathway involves activation of an amino acid
by aminoacyl-tRNA-synthetase, which reacts with an aromatic hydroxylamine to
form a reactive N-ester (Kato and Yamazoe 1994).Carboxylic acids, particularly aromatic acids and aryl acetic acids, are conjugated with polar endogenous amino acids.
The quantity of amino acid conjugation is minute because of the limited availability
of amino acids in the body and competition with glucuronidation for carboxylic acid
substrates. Amino acids conjugation of carboxylic acids leads to amide bond formaFig. 5.6 Sulfation
Fig. 5.7 Methylation
Fig. 5.8 Acetylation
5 Biotransformation Enzymes
amino acids as serine and proline. This pathway involves activation of an amino acid
by aminoacyl-tRNA-synthetase, which reacts with an aromatic hydroxylamine to
form a reactive N-ester (Kato and Yamazoe 1994).Carboxylic acids, particularly aromatic acids and aryl acetic acids, are conjugated with polar endogenous amino acids.
The quantity of amino acid conjugation is minute because of the limited availability
of amino acids in the body and competition with glucuronidation for carboxylic acid
substrates. Amino acids conjugation of carboxylic acids leads to amide bond formaFig. 5.6 Sulfation
Fig. 5.7 Methylation
Fig. 5.8 Acetylation
5 Biotransformation Enzymes