Novel Screen Methodologies for Identification of New Microbial Metabolites
79
T
.
L....~L
A.L
y.,
y
_
~- v
y
-o.
~"~o
o A
'
O,~K.,.N/
~
-r )--, ~o
L .L ..L L..;'---d
.... =Y Y rr3 2'
H2 N OH
H~
O
OH
I
O=P-ONa
I
O OH
o~~~ ~~-~
~N ~NH
~N~OCH3
NHCH 3
Fig. 1. Structures of the immunosuppressants FR901459, 1, and myriocin, 2 (Sect. 2.1.2), the cell
adhesion inhibitor cytostatin, 3 (Sect. 2.1.3), and the macrophage activation promoter TAN-999,
4 (Sect. 2.1.4)
79
T
.
L....~L
A.L
y.,
y
_
~- v
y
-o.
~"~o
o A
'
O,~K.,.N/
~
-r )--, ~o
L .L ..L L..;'---d
.... =Y Y rr3 2'
H2 N OH
H~
O
OH
I
O=P-ONa
I
O OH
o~~~ ~~-~
~N ~NH
~N~OCH3
NHCH 3
Fig. 1. Structures of the immunosuppressants FR901459, 1, and myriocin, 2 (Sect. 2.1.2), the cell
adhesion inhibitor cytostatin, 3 (Sect. 2.1.3), and the macrophage activation promoter TAN-999,
4 (Sect. 2.1.4)