30
J. Gomes and A.S. Menawat
16
700
600
.g
20o
12 C
-,,..~
g
3
4 ~
"'~e
-
1|
'.
Jo~
0
24
48
72
96
120
144
Time (h)
Fig. 13. Fed-batch bioproduction of spectinomycin with glucose feed concentration of 200 g 1-t,
9 glucose concentration; 9 spectinomycin concentration; -- model fit for spectinomycin concentration; ---- model fit for glucose concentration
75
600
r~
o
o ~400
.~
C
5O ,~
o
0
2s ~
700
f"
~
..
.~.~
,,9
e
/
9 o~
/
/"
9
~176
9
I
/
/~
/
/
I00 "'~
o/.~'~
9
0
,
~./-~r-~-~-t
0,
9
. 4~
.
,
,
,
. . . . . . . . .
o
0
24
48
72
96
120
144
Time (h)
Fig. 14. Fed-batch bioproduction of spectinomycin with glucose feed concentration of 400 gl-t.
9 glucose concentration; 9 spectinomycin concentration; -- model fit for spectinomycin concentration; ---- model fit for glucose concentration