Preface
This book includes selected papers presented at the XlIth International Conference on Methods in Protein Structure Analysis
(MPSA), which took place in Halkidiki, Greece, in September
1998, under a scientific atmosphere, good weather and the spirit
of the greek philosopher Aristotle, who was born in that area of
Greece. To insure the highest quality and the most rapid publication, the MPSA Book Advisory subcommittee has chosen for the
book the most interesting and useful presentations from the
meeting. This book includes papers covering new, sensitive and
rapid methodologies, as well as various aspects of the Protein
Chemistry field, reflecting the multidisciplinary nature of the
problems concerning the analysis of the total cell proteins, namely
proteome, a term which was first used in 1994 at the Siena 2DElectrophoresis meeting. So, we finally decided on the title of
"Proteome and Protein Analysis", which indeed corresponds to
our thoughts and to the wishes of most scientists, as we believe, in
the protein area.
Several methodologies from different fields, like Edman degradation, DNA sequencing, mass spectrometry have to be combined
for an elaborate study of proteins' function in biological processes. For example the combination of mass spectrometry techniques with proteome analysis answers a large number of scientific questions.
Different mass spectrometry methods such as MALDI, ESI - or
Nano Electrospray are described and discussed for their use in
proteome and protein analysis. The importance of the mass spectrometry in proteome and protein analysis was acknowledged with
the presentation of the Edman Award 1998 to three mass spectrometry experts: Matthias Mann, Matthias Wilm and John Yates.
We believe that this book contains new and interesting contributions to bioscience, describing new methodologies, new developments on structural studies, functional implication of proteins,
NMR analysis, database searches of multi-alignments and mass
spectrometry analysis of proteins.
The chapters have been written by scientists with extensive
experience in these fields. The contributors of this volume are all
This book includes selected papers presented at the XlIth International Conference on Methods in Protein Structure Analysis
(MPSA), which took place in Halkidiki, Greece, in September
1998, under a scientific atmosphere, good weather and the spirit
of the greek philosopher Aristotle, who was born in that area of
Greece. To insure the highest quality and the most rapid publication, the MPSA Book Advisory subcommittee has chosen for the
book the most interesting and useful presentations from the
meeting. This book includes papers covering new, sensitive and
rapid methodologies, as well as various aspects of the Protein
Chemistry field, reflecting the multidisciplinary nature of the
problems concerning the analysis of the total cell proteins, namely
proteome, a term which was first used in 1994 at the Siena 2DElectrophoresis meeting. So, we finally decided on the title of
"Proteome and Protein Analysis", which indeed corresponds to
our thoughts and to the wishes of most scientists, as we believe, in
the protein area.
Several methodologies from different fields, like Edman degradation, DNA sequencing, mass spectrometry have to be combined
for an elaborate study of proteins' function in biological processes. For example the combination of mass spectrometry techniques with proteome analysis answers a large number of scientific questions.
Different mass spectrometry methods such as MALDI, ESI - or
Nano Electrospray are described and discussed for their use in
proteome and protein analysis. The importance of the mass spectrometry in proteome and protein analysis was acknowledged with
the presentation of the Edman Award 1998 to three mass spectrometry experts: Matthias Mann, Matthias Wilm and John Yates.
We believe that this book contains new and interesting contributions to bioscience, describing new methodologies, new developments on structural studies, functional implication of proteins,
NMR analysis, database searches of multi-alignments and mass
spectrometry analysis of proteins.
The chapters have been written by scientists with extensive
experience in these fields. The contributors of this volume are all