362
N. K. KARAMANOS
Iozzo RV (1997) The family of the small leucine-rich proteoglycans: key regulators of matrix assembly
and cellular growth. Crit Rev Biochem Mol Bioi 32: 141-174
Karamanos NK, Hjerpe A, Tsegenidis T, Engfeld B, Antonopoulos CA (1988) Determination of iduronic and glucuronic acid in glycosaminoglycans after stoichiometric reduction and depolymerization using high-performance liquid chromatography and ultraviolet detection. Anal Biochem 172:
410-419
Karamanos NK (1992) High-performance liquid chromatographic determination of xylitole and hexosaminitols present in the reduced terminal of glycosaminoglycans. J Liq Chromatogr 16:
2639-2652
Karamanos NK, Aletras AJ, Tsegenidis T, Tsiganos CP, Antonopoulos CA (1992) Isolation, characterization and properties of the oversulphated chondroitin sulphate proteoglycan from squid skin
with peculiar glycosaminoglycan sulphation pattern. Eur J Biochem 204: 553-560
Karamanos NK, Syrokou A, Vanky P, Nurminen M, Hjerpe A (1994) Determination of 24 variously
sulfated galactosaminoglycan- and hyaluronan-derived disaccharides by high-performance liquid
chromatography. Anal Biochem 221: 189-199
Karamanos NK, Axelson S, Vanky P, Tzanakakis GN, Hjerpe A (1995a) Determination ofhyaluronan and
galactosaminoglycan disaccharides by high-performance capillary electrophoresis at the attomole
level. Application to analyses of tissue and cell culture proteoglycans. J Chromatogr A 696: 295-305
Karamanos NK, Vanky P, Syrokou A, Hjerpe A (I995b) Identity of dermatan and chondroitin
sequences in dermatan sulfate chains by using fragmentation with chondroitinases and ion-pair
high-performance liquid chromatography. Anal Biochem 225: 220-230
Karamanos NK, Hjerpe A (1996) Strategy to characterize sequences of uronic acid-containing glycosaminoglycans by high-performance liquid chromatography and capillary electrophoresis. In: Balduini C, Cherubikno C, De Luca G (eds) Advances in Biomedical Studies: Biology and Physiopathology of the Extracellular Matrix. La Goliardica Pavese, Pavia, vol II, pp 71-82
Karamanos NK, Vanky P, Tzanakakis GN, Hjerpe A (1996) High-performance capillary electrophoresis to characterize heparin and heparan sulfate disaccharides. Electrophoresis 17: 391-395
Karamanos NK (1997) Structure-function relationship of glycoconjugates and their role in diagnosis
and treatment. Farmakeftiki 10: 50-61
Karamanos NK, Hjerpe A (1997) High-performance capillary electrophoretic analysis ofhyaluronan
in effusions from human malignant mesothelioma. J Chromatogr B 697: 277-281
Karamanos NK, Vanky P, Tzanakakis GN, Tsegenidis T, Hjerpe A (1997) Ion-pair high-performance
liquid chromatography for determining disaccharide composition of heparin and heparan sulfate.
J Chromatogr A 765: 169-179.
Karamanos NK, Hjerpe A (1998) An survey of methodological challenges for glycosaminoglycan/proteo glycan analysis and structural characterization by capillary electrophoresis. Electrophoresis 19:
2561-2571
Karamanos NK, Lamari F, Katsimpris J, Gartaganis S (1999) Development of an HPLC method for
determining the alpha2-adrenergic receptor agonist brimonidine in blood serum and aqueous
humor of the eye. Biomed. Chromatogr. 13: 86-88
Khellen L, Lindahl U (1991) Proteoglycans: structures and interactions. Ann Rev Biochem 60:
867-869
Kuhn R (1993) Capillary electrophoresis: principles and practise. Springer-Verlag, London
Lamari F, Karamanos NK (1999) High-performance capillary electrophoresis as a powerful analytical
tool of glycoconjugates. J Liq Chrom & Rei Technol 22 "in press"
Lamari F, Katsimpris J, Gartaganis S, Karamanos NK (1998) Profiling of the eye aqueous humor in
exfoliation syndrome by high-performance liquid chromatographic analysis of hyaluronan and
galactosaminopglycans. J Chromatogr B 709: 173 -178
Laurent T, Fraser JR (1992) Hyaluronan FASEB J 6: 2397-2404
Lindahl U (1989) Heparin: chemical and biological properties, clinical applications. In: Lane D, Lindahl U (eds). CRC press, Boca Raton, FL, USA
Nurminen M, Dejmek A, Martensson G, Thylen A, Hjerpe A (1994) Clinical utility of liquidchromatographic analysis of effusions for hyaluronate content. Clin Chern 40: 777-780
Prehm P (1984) Hyaluronate is synthesized at plasma membrane. Biochem J 220: 597-600
Syrokou A, Tzanakakis GN, Tsegenidis T, Hjerpe A, Karamanos NK (1999) Effects of glycosaminoglycans in proliferation of epithelial and fibroblast human malignant mesothelioma cells. A structurefunction relationship. Cell Prolif 32 " in press"
Takeuchi Y, Yanagishita M, Hascall VC (I 992) Recycling of transferrin receptors and heparan sulfate
proteoglycans in a rat parathyroid cell line. J Bioi Chern 25: 14685-14690
Tzanakakis GN, Karamanos NK, Hjerpe A (1995) Effects on glycosaminoglycan synthesis in cultured
malignant mesothelioma cells of transforming, epidermal and fibroblast growth factors and their
combinations with platelet-derived growth factor. Exp Cell Res 220: 130-137
N. K. KARAMANOS
Iozzo RV (1997) The family of the small leucine-rich proteoglycans: key regulators of matrix assembly
and cellular growth. Crit Rev Biochem Mol Bioi 32: 141-174
Karamanos NK, Hjerpe A, Tsegenidis T, Engfeld B, Antonopoulos CA (1988) Determination of iduronic and glucuronic acid in glycosaminoglycans after stoichiometric reduction and depolymerization using high-performance liquid chromatography and ultraviolet detection. Anal Biochem 172:
410-419
Karamanos NK (1992) High-performance liquid chromatographic determination of xylitole and hexosaminitols present in the reduced terminal of glycosaminoglycans. J Liq Chromatogr 16:
2639-2652
Karamanos NK, Aletras AJ, Tsegenidis T, Tsiganos CP, Antonopoulos CA (1992) Isolation, characterization and properties of the oversulphated chondroitin sulphate proteoglycan from squid skin
with peculiar glycosaminoglycan sulphation pattern. Eur J Biochem 204: 553-560
Karamanos NK, Syrokou A, Vanky P, Nurminen M, Hjerpe A (1994) Determination of 24 variously
sulfated galactosaminoglycan- and hyaluronan-derived disaccharides by high-performance liquid
chromatography. Anal Biochem 221: 189-199
Karamanos NK, Axelson S, Vanky P, Tzanakakis GN, Hjerpe A (1995a) Determination ofhyaluronan and
galactosaminoglycan disaccharides by high-performance capillary electrophoresis at the attomole
level. Application to analyses of tissue and cell culture proteoglycans. J Chromatogr A 696: 295-305
Karamanos NK, Vanky P, Syrokou A, Hjerpe A (I995b) Identity of dermatan and chondroitin
sequences in dermatan sulfate chains by using fragmentation with chondroitinases and ion-pair
high-performance liquid chromatography. Anal Biochem 225: 220-230
Karamanos NK, Hjerpe A (1996) Strategy to characterize sequences of uronic acid-containing glycosaminoglycans by high-performance liquid chromatography and capillary electrophoresis. In: Balduini C, Cherubikno C, De Luca G (eds) Advances in Biomedical Studies: Biology and Physiopathology of the Extracellular Matrix. La Goliardica Pavese, Pavia, vol II, pp 71-82
Karamanos NK, Vanky P, Tzanakakis GN, Hjerpe A (1996) High-performance capillary electrophoresis to characterize heparin and heparan sulfate disaccharides. Electrophoresis 17: 391-395
Karamanos NK (1997) Structure-function relationship of glycoconjugates and their role in diagnosis
and treatment. Farmakeftiki 10: 50-61
Karamanos NK, Hjerpe A (1997) High-performance capillary electrophoretic analysis ofhyaluronan
in effusions from human malignant mesothelioma. J Chromatogr B 697: 277-281
Karamanos NK, Vanky P, Tzanakakis GN, Tsegenidis T, Hjerpe A (1997) Ion-pair high-performance
liquid chromatography for determining disaccharide composition of heparin and heparan sulfate.
J Chromatogr A 765: 169-179.
Karamanos NK, Hjerpe A (1998) An survey of methodological challenges for glycosaminoglycan/proteo glycan analysis and structural characterization by capillary electrophoresis. Electrophoresis 19:
2561-2571
Karamanos NK, Lamari F, Katsimpris J, Gartaganis S (1999) Development of an HPLC method for
determining the alpha2-adrenergic receptor agonist brimonidine in blood serum and aqueous
humor of the eye. Biomed. Chromatogr. 13: 86-88
Khellen L, Lindahl U (1991) Proteoglycans: structures and interactions. Ann Rev Biochem 60:
867-869
Kuhn R (1993) Capillary electrophoresis: principles and practise. Springer-Verlag, London
Lamari F, Karamanos NK (1999) High-performance capillary electrophoresis as a powerful analytical
tool of glycoconjugates. J Liq Chrom & Rei Technol 22 "in press"
Lamari F, Katsimpris J, Gartaganis S, Karamanos NK (1998) Profiling of the eye aqueous humor in
exfoliation syndrome by high-performance liquid chromatographic analysis of hyaluronan and
galactosaminopglycans. J Chromatogr B 709: 173 -178
Laurent T, Fraser JR (1992) Hyaluronan FASEB J 6: 2397-2404
Lindahl U (1989) Heparin: chemical and biological properties, clinical applications. In: Lane D, Lindahl U (eds). CRC press, Boca Raton, FL, USA
Nurminen M, Dejmek A, Martensson G, Thylen A, Hjerpe A (1994) Clinical utility of liquidchromatographic analysis of effusions for hyaluronate content. Clin Chern 40: 777-780
Prehm P (1984) Hyaluronate is synthesized at plasma membrane. Biochem J 220: 597-600
Syrokou A, Tzanakakis GN, Tsegenidis T, Hjerpe A, Karamanos NK (1999) Effects of glycosaminoglycans in proliferation of epithelial and fibroblast human malignant mesothelioma cells. A structurefunction relationship. Cell Prolif 32 " in press"
Takeuchi Y, Yanagishita M, Hascall VC (I 992) Recycling of transferrin receptors and heparan sulfate
proteoglycans in a rat parathyroid cell line. J Bioi Chern 25: 14685-14690
Tzanakakis GN, Karamanos NK, Hjerpe A (1995) Effects on glycosaminoglycan synthesis in cultured
malignant mesothelioma cells of transforming, epidermal and fibroblast growth factors and their
combinations with platelet-derived growth factor. Exp Cell Res 220: 130-137