1 Introduction to the Detection of DNA Strand Breaks
11
combined use of in situ tailing and nick translation techniques. Lab
Invest 71:219-225
Greer WL, Kaplan JG (1984) Regulation of repair of naturally occurring
DNA strand breaks in lymphocytes. Biochem Biophys Res Commun
122:366-372
Hashimoto S, Koji T, Niu J, Kanematsu T, Nakane PK (1995) Differential
staining of DNA strand breaks in dying cells by non-radioactive in situ
nick translation. Arch Histol Cytol 58: 161-170
Hashimoto S, Koji T, KoharaN, Kanematsu T, Nakane PK (1997) Frequency
of apoptosis relates inversely to invasiveness and metastatic activity in
human colorectal cancer. Virchows Arch 431:241-248
Johnstone AP, Williams GT (1982) Role of DNA breaks and ADP-ribosyl
transferase activity in eukaryotic differentiation demonstrated in human
lymphocytes. Nature 300:368-370
Jostes R, Reese JA, Cleaver JE, Molero M, Morgan WF (1989) Quiescent human lymphocytes do not contain DNA strand breaks detectable by alkaline elution. Exp Cell Res 182:5l3-520
Kerem B, Goitein R, Diamond G, Cedar H, Marcus M (1984) Mapping of
DNase-I sensitive regions on mitotic chromosomes. Cell 38:493-499
Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Brit J Cancer
26:239-257
Koji T (1996) Nonradioactive in situ nick translation: A useful molecular
histochemical tool to detect single-stranded DNA breaks. Acta Histochern Cytochem 29:71-79
Koji T, Brenner RM (1993) Localization of estrogen receptor messenger ribonucleic acid in rhesus monkey uterus by nonradioactive in situ hybridization with digoxigenin-Iabeled oligodeoxynucleotides. Endocrinology l32:382-392
Koji T, Nakane PK (1996) Recent advances in molecular histochemical techniques: In situ hybridization and southwestern histochemistry. J Electron Microsc 45:119-127
Koji T, WangR-A (1998) Male germ cell death in mouse testes. In: Yamada T
and Hashimoto Y (ed) Apoptosis: Mechanism and Function. Business
Ctr Acad Soc Japan, Tokyo, p.85-96
Ma L (1995) Mammalian nucleotide repair. Biochim Biophys Acta 1242:
l37-164
Nogae S, Miyazaki M, Kobayashi N, Saito T, Abe K, Saito H, Nakane PK,
Nakanishi Y, Koji T (1988) Induction of apoptosis in ischemia-reperfusion model of mouse kidney: Possible involvement of Fas. J Am Soc
N ephrol,9:620-631
Ogawa T, Okazaki T (1980) Discontinuous DNA replication. Annu Rev
Biochem 49: 421-457
Peitsch MC, Muller C, Tschopp J (1993) DNA fragmentation during apoptosis is caused by frequent single-strand cuts. Nucl Acids Res 21:42064209
Prasad KV, Greer WL, Severini A, Kaplan JG (1987) Increase in intercellular
Na+: Transmembrane signal for rejoining of DNA strand breaks in proliferating lymphocytes. Cancer Res 47:5397-5400
11
combined use of in situ tailing and nick translation techniques. Lab
Invest 71:219-225
Greer WL, Kaplan JG (1984) Regulation of repair of naturally occurring
DNA strand breaks in lymphocytes. Biochem Biophys Res Commun
122:366-372
Hashimoto S, Koji T, Niu J, Kanematsu T, Nakane PK (1995) Differential
staining of DNA strand breaks in dying cells by non-radioactive in situ
nick translation. Arch Histol Cytol 58: 161-170
Hashimoto S, Koji T, KoharaN, Kanematsu T, Nakane PK (1997) Frequency
of apoptosis relates inversely to invasiveness and metastatic activity in
human colorectal cancer. Virchows Arch 431:241-248
Johnstone AP, Williams GT (1982) Role of DNA breaks and ADP-ribosyl
transferase activity in eukaryotic differentiation demonstrated in human
lymphocytes. Nature 300:368-370
Jostes R, Reese JA, Cleaver JE, Molero M, Morgan WF (1989) Quiescent human lymphocytes do not contain DNA strand breaks detectable by alkaline elution. Exp Cell Res 182:5l3-520
Kerem B, Goitein R, Diamond G, Cedar H, Marcus M (1984) Mapping of
DNase-I sensitive regions on mitotic chromosomes. Cell 38:493-499
Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Brit J Cancer
26:239-257
Koji T (1996) Nonradioactive in situ nick translation: A useful molecular
histochemical tool to detect single-stranded DNA breaks. Acta Histochern Cytochem 29:71-79
Koji T, Brenner RM (1993) Localization of estrogen receptor messenger ribonucleic acid in rhesus monkey uterus by nonradioactive in situ hybridization with digoxigenin-Iabeled oligodeoxynucleotides. Endocrinology l32:382-392
Koji T, Nakane PK (1996) Recent advances in molecular histochemical techniques: In situ hybridization and southwestern histochemistry. J Electron Microsc 45:119-127
Koji T, WangR-A (1998) Male germ cell death in mouse testes. In: Yamada T
and Hashimoto Y (ed) Apoptosis: Mechanism and Function. Business
Ctr Acad Soc Japan, Tokyo, p.85-96
Ma L (1995) Mammalian nucleotide repair. Biochim Biophys Acta 1242:
l37-164
Nogae S, Miyazaki M, Kobayashi N, Saito T, Abe K, Saito H, Nakane PK,
Nakanishi Y, Koji T (1988) Induction of apoptosis in ischemia-reperfusion model of mouse kidney: Possible involvement of Fas. J Am Soc
N ephrol,9:620-631
Ogawa T, Okazaki T (1980) Discontinuous DNA replication. Annu Rev
Biochem 49: 421-457
Peitsch MC, Muller C, Tschopp J (1993) DNA fragmentation during apoptosis is caused by frequent single-strand cuts. Nucl Acids Res 21:42064209
Prasad KV, Greer WL, Severini A, Kaplan JG (1987) Increase in intercellular
Na+: Transmembrane signal for rejoining of DNA strand breaks in proliferating lymphocytes. Cancer Res 47:5397-5400