80
J. A. BURNS
Table 1. Sensitivity coefficient of fluxes with respect to enzymes.
Coefficient off; with respect to eJ = 100 X (dji/f;)f(dejfej)
Fl
F2
F3
F4
F5
F6
F7
F8
F9 FlO
El
24
24
24
24
25
25
25
25
25
25
E2
15
15
15
15
15
15
15
15
15
15
E3
4
4
4
4
4
4
4
4
4
4
E4
1
1
1
1
1
1
1
1
1
1
E5
-17 -17 -17 -17
17
17
17 -49 -49 -49
E6
-6
-6
-6
-6
6
6
6 -16 -16 -16
E7
46
46
46
46
51
51
51
43
43
43
E8
17
17
17
17 -16 -16 -16
51
51
51
E9
5
5
5
5
-5
-5
-5
17
17
17
E10
1
1
1
1
-2
-2
-2
6
6
6
Sum I 90 90 90 90 95 95 95 96 96 96
References
1. Edinburgh University Computer Unit. Report No.4.
2. CLELAND, W. W.: Biochem. BiophysicaActa 67,104 (1963).
Discussion
WALTER:
Do you assume all steps are far from equilibrium?
BURNS:
We make no approximations other than those implicit in our use of "net flux"
expressions.