Coactive Regulatory ~[echanisms Realizing Optimal Autoregulation 201
opinion on the existence of an optimum aim as "an internally given criterion",
it is especially emphasized in mv paper that self-regulating and not regulating
mechanisms were studied.- The regulatory loop within the system, connecting
the feedback of the regulated network with the regulating enzyme system is
closed; the effectiveness of this loop is a necessary condition set by the environment. Thus, in the interaction with the e)dernal environment during evolutionary
processes, bv means of which the optimal solutions achieved in the individual
development have been selected, organisms succeeded in developing loops
most appropriate to a \vell suited internal organization. We do not try to
definitely explain evolution by thermodynamic principles; we only use a thermodynamic value such as a functional as long as intimate molecular mechanisms
are vastly unknown. The maximum principle, to which this thermodynamic
value is subordinated as a functional expressing the aim of an organism in the
transition from nne steady-state to another, is not contradictory to evolution.
The control mechanisms in different organisms are universal since the fundamental biological laws are equally valid for all living beings; yet, different
ecological conditions ha V'C led to a differentiation between and within the
organisms.
(Further mootpoints of the discussion were: The questionability of the proposed approach to a Hamiltonian or Lagrangian formulation in classical mechanics;
the question whether the formulation proposed does help to compute anything;
the problem how the choice of the functional was related to the control loops;
finally, the problem to predict from the physical1aws how a species will survive in
the evolutionary scheme, The Editor.)
opinion on the existence of an optimum aim as "an internally given criterion",
it is especially emphasized in mv paper that self-regulating and not regulating
mechanisms were studied.- The regulatory loop within the system, connecting
the feedback of the regulated network with the regulating enzyme system is
closed; the effectiveness of this loop is a necessary condition set by the environment. Thus, in the interaction with the e)dernal environment during evolutionary
processes, bv means of which the optimal solutions achieved in the individual
development have been selected, organisms succeeded in developing loops
most appropriate to a \vell suited internal organization. We do not try to
definitely explain evolution by thermodynamic principles; we only use a thermodynamic value such as a functional as long as intimate molecular mechanisms
are vastly unknown. The maximum principle, to which this thermodynamic
value is subordinated as a functional expressing the aim of an organism in the
transition from nne steady-state to another, is not contradictory to evolution.
The control mechanisms in different organisms are universal since the fundamental biological laws are equally valid for all living beings; yet, different
ecological conditions ha V'C led to a differentiation between and within the
organisms.
(Further mootpoints of the discussion were: The questionability of the proposed approach to a Hamiltonian or Lagrangian formulation in classical mechanics;
the question whether the formulation proposed does help to compute anything;
the problem how the choice of the functional was related to the control loops;
finally, the problem to predict from the physical1aws how a species will survive in
the evolutionary scheme, The Editor.)