100
E. ZERBST
ments on capacity adaptation to temperature. The results obtained are in
principle well consistent with predictiQns made on the basis of the hypothesis on flux equilibrium in the metabolism of the pacemaker system. The
special set-up of these experiments was derived from the theories of open
systems and irreversible thermodynamics. The application of these theories
to physiological experiments appears promising.
References
1. BERTALANFFY, L. v.: Biophysik des FlieBgleichgewichts. Braunschweig: Vieweg 1953.
2. BURTON, A. c.: J. cell. compo Physiol. 14, 327 (1939).
3. WILLIAM, E., u. E. ZERBST: Z. wirtsch. Fertigg. (to appear 1968).
4. - - Intern. elektron. Rdsch. 4, 100 (1967).
5. ZERBST, E.: Helgolander wiss. Meeresunters. 14, 51 (1966).
6. -, G. HENNERSDORF u. H. v. BRAMANN: II. Intern. Kongr. Biophysik, Wien,
Sept. 1966.
Discussion
GRAINGER:
DENBIGH, HICKS and PAGE have shown that it is possible to get "false start"
transients in your theoretical system. Have you found these?
ZERBST:
We never found "false start" transitions in the object under discussion.
SMITH:
The model would appear to require consideration of the possible role of divalent cations.
ZERBST:
We plan to investigate the role of Ca++ and of other divalent cations in further
experiments. So far, we only know that Ca++ influences the permeability, i.e.
the coefficients for passive fluxes of sodium and potassium in our more complex model.
CHRISTOPHERSEN:
You have described the changes of metabolic rates induced by change in the
experimental temperature as temperature adaptation. I would like to draw
your attention to the concept of temperature adaptation after PRECHT, PROSSER
et aI., who agree in the opinion that 3 phases are to be distinguished in the
time course of temperature-induced changes of performance activities: (1) a
step change of the rate, frequently demonstrating an "overshoot" in activity.
(2) a readjustment of a new steady state and (3) a slow compensation of the
rate which in the ideal case may lead back to the original activity. The last
mentioned compensation is accompanied by changes in the parameters, e.g.
enzyme concentrations, etc. Only such a compensation should correctly be
E. ZERBST
ments on capacity adaptation to temperature. The results obtained are in
principle well consistent with predictiQns made on the basis of the hypothesis on flux equilibrium in the metabolism of the pacemaker system. The
special set-up of these experiments was derived from the theories of open
systems and irreversible thermodynamics. The application of these theories
to physiological experiments appears promising.
References
1. BERTALANFFY, L. v.: Biophysik des FlieBgleichgewichts. Braunschweig: Vieweg 1953.
2. BURTON, A. c.: J. cell. compo Physiol. 14, 327 (1939).
3. WILLIAM, E., u. E. ZERBST: Z. wirtsch. Fertigg. (to appear 1968).
4. - - Intern. elektron. Rdsch. 4, 100 (1967).
5. ZERBST, E.: Helgolander wiss. Meeresunters. 14, 51 (1966).
6. -, G. HENNERSDORF u. H. v. BRAMANN: II. Intern. Kongr. Biophysik, Wien,
Sept. 1966.
Discussion
GRAINGER:
DENBIGH, HICKS and PAGE have shown that it is possible to get "false start"
transients in your theoretical system. Have you found these?
ZERBST:
We never found "false start" transitions in the object under discussion.
SMITH:
The model would appear to require consideration of the possible role of divalent cations.
ZERBST:
We plan to investigate the role of Ca++ and of other divalent cations in further
experiments. So far, we only know that Ca++ influences the permeability, i.e.
the coefficients for passive fluxes of sodium and potassium in our more complex model.
CHRISTOPHERSEN:
You have described the changes of metabolic rates induced by change in the
experimental temperature as temperature adaptation. I would like to draw
your attention to the concept of temperature adaptation after PRECHT, PROSSER
et aI., who agree in the opinion that 3 phases are to be distinguished in the
time course of temperature-induced changes of performance activities: (1) a
step change of the rate, frequently demonstrating an "overshoot" in activity.
(2) a readjustment of a new steady state and (3) a slow compensation of the
rate which in the ideal case may lead back to the original activity. The last
mentioned compensation is accompanied by changes in the parameters, e.g.
enzyme concentrations, etc. Only such a compensation should correctly be