1. Models of Metabolism
1.1. Models in General
Contents
1 A. LOCKER: The Epistemological Significance of Models in Science
1
2 H. KACSER, and J. A. BURNS: Causality, Complexity and Computers
11
1.2. Discrete and Continuous Models
3 R. ROSEN: Discrete and Continuous Representations of Metabolic
Models . . . . . . . . . . . . . . . . . . . . . . . . . .
24
4 M. SUGITA: Interaction of a Digital (Genetic) System with a Continuous (Enzymatic) One in the Cell . . . . . . . . . . . . .
33
5 CH. WALTER: A Model for Sustained Rhythmic Binary Logic in
Biochemical Systems
. . . . . . . . . . . . . . . .
38
1.3 Stochastic and Deterministic Models
6 A. F. BARTHOLmIAY: Some General Ideas on Deterministic and
Stochastic Models in Biological Systems . . . . . . . . . . . .
45
7 P.-E. E. BERGNER: Turnover Compartmentalization. An Approach
to Analysis of Whole-body Retention Data . . . . . . . . . .
66
1.4 Computer Models of Cell Metabolism
8 Z. SIMON, D. FARCAS, and A. CRISTEA: Functioning of a Cell Model
71
9 J. A. BURNS: A Digital Computer System for the Construction and
Analysis of Steady State Models of Enzyme Catalysed Networks.
75
10 H. J. BRBIERMANN: Computation of Equilibria and Kinetics of
Chemical SYstems with Many Species. . . . . . . . . . . . .
81
2. Metabolic Parameters
2.1 Temperature - Season - Adaptation
11 J. N. R. GRAINGER: The Relation between Heat Production, Oxygen Consumption and Temperature in Some Poikilotherms. . . .
86
12 H.-D. JANKOWSKY: On Structure and Metabolic Rate of the Skeletal
Muscle of the Eel (Anguilla vulgaris L.) . . . . . . . . . . ..
91
13 E. ZERBST: Analvsis of Heart Rate Adaptation to Temperature..
95
14 S. GELINEO: The Heat Production of Goldfinches and Canaries in
Summer and Winter . . . . . . . . . . . . . . . . . . . .
102
15 R. E. S~IITH, BARBARA A. HORWITZ, and Y. IMAI: Quantitative Thermogenesis of Brown Fat in Hibernation and Cold Adaptation
106
2.2 Growtb - Age
16 F. KRUGER: Contributions to the Energetics of Animal Growth.
113
17 P. R. PAYNE, and ERICA F. WHEELER: Models of the Growth of
Organisms under Nutrient Limiting Conditions . . . . . . . .
127
1.1. Models in General
Contents
1 A. LOCKER: The Epistemological Significance of Models in Science
1
2 H. KACSER, and J. A. BURNS: Causality, Complexity and Computers
11
1.2. Discrete and Continuous Models
3 R. ROSEN: Discrete and Continuous Representations of Metabolic
Models . . . . . . . . . . . . . . . . . . . . . . . . . .
24
4 M. SUGITA: Interaction of a Digital (Genetic) System with a Continuous (Enzymatic) One in the Cell . . . . . . . . . . . . .
33
5 CH. WALTER: A Model for Sustained Rhythmic Binary Logic in
Biochemical Systems
. . . . . . . . . . . . . . . .
38
1.3 Stochastic and Deterministic Models
6 A. F. BARTHOLmIAY: Some General Ideas on Deterministic and
Stochastic Models in Biological Systems . . . . . . . . . . . .
45
7 P.-E. E. BERGNER: Turnover Compartmentalization. An Approach
to Analysis of Whole-body Retention Data . . . . . . . . . .
66
1.4 Computer Models of Cell Metabolism
8 Z. SIMON, D. FARCAS, and A. CRISTEA: Functioning of a Cell Model
71
9 J. A. BURNS: A Digital Computer System for the Construction and
Analysis of Steady State Models of Enzyme Catalysed Networks.
75
10 H. J. BRBIERMANN: Computation of Equilibria and Kinetics of
Chemical SYstems with Many Species. . . . . . . . . . . . .
81
2. Metabolic Parameters
2.1 Temperature - Season - Adaptation
11 J. N. R. GRAINGER: The Relation between Heat Production, Oxygen Consumption and Temperature in Some Poikilotherms. . . .
86
12 H.-D. JANKOWSKY: On Structure and Metabolic Rate of the Skeletal
Muscle of the Eel (Anguilla vulgaris L.) . . . . . . . . . . ..
91
13 E. ZERBST: Analvsis of Heart Rate Adaptation to Temperature..
95
14 S. GELINEO: The Heat Production of Goldfinches and Canaries in
Summer and Winter . . . . . . . . . . . . . . . . . . . .
102
15 R. E. S~IITH, BARBARA A. HORWITZ, and Y. IMAI: Quantitative Thermogenesis of Brown Fat in Hibernation and Cold Adaptation
106
2.2 Growtb - Age
16 F. KRUGER: Contributions to the Energetics of Animal Growth.
113
17 P. R. PAYNE, and ERICA F. WHEELER: Models of the Growth of
Organisms under Nutrient Limiting Conditions . . . . . . . .
127