20
FRIEDHEL M H ILDEBRA NDT
TRANSCAIPTION: REGULATION AND TISSUE SPECIFICITY
enhancers and
repressors
mediate regulation by signal
transduction
the presence of
TFs mediates
tissue
specificity
bindung
sites for
enhancer
transcription TATAstart of transcriptlon
reg ien
fac;t-,
Box
.2:::J. - - -__,j_....._-.....6~~~
>- 100
-25
e. g.: • gtucocorticoid
responsive
element"
(GRE)
AT-fich
e. g.:
- CMT-box
- SPl binding
profein
- CG-rich region
in " housekeeptng
genas•
A
2 Transcripts from 1 gene result ing from
alternative splicing or alternative promoters
genomic
P 2
P 1
DNA
• • - - - - - - - - - - - • •
1 transcrip - 1
/\ = i ntron
ftion
.~
hnRNA
s plicing
mRNA
j "ao.latioo
polypeptido 1 = short
polypeptide 2 = lon g
-
1
2
transcript
1
2.
-
Fig. 11. Regulation of transcription. For details see text.
= exon
=rad i o -
ac l i ve
prob e
B