136
M. Christmann
5
Conclusion
We have shown organocatalysis to be a powerful tool for the synthesis
of drugs and natural products. Our work and that of others have clearly
demonstrated that organocatalytic strategies can cut down the total number of synthetic operations. As organocatalysts are usually non-toxic,
air- and moisture-stable and often available from renewable sources,
they are destined to have an impact on the development of future sustainable chemical processes.
Acknowledgements. I would like to thank the Fonds der Chemischen Industrie for a Liebig fellowship, the Deutsche Forschungsgemeinschaft for funding
(SPP1179 Organokatalyse) and Prof. Dieter Enders for his encouragement and
support.
References
Agatsuma T, Akama T, Nara S, Matsumiya S, Nakai R, Ogawa H, Otaki S, Ikeda
S, Saitoh Y, Kanda Y (2002) UCS1025A and B, new antitumor antibiotics
from the fungus Acremonium species. Org Lett 4:4387–4390
de Figueiredo RM, Christmann M (2007) Organocatalytic synthesis of drugs
and bioactive natural products. Eur J Org Chem 2575–2600
de Figueiredo RM, Fröhlich R, Christmann M (2006) N,N -Carbonyldiimidazole-mediated cyclization of amino alcohols to substituted azetidines and
other N-heterocycles. J Org Chem 71:4147–4154
de Figueiredo RM, Berner R, Julis J, Liu T, Türp D, Christmann M (2007)
Bidirectional, organocatalytic synthesis of lepidopteran sex pheromones.
J Org Chem 72:640–642
de Figueiredo RM, Fröhlich R, Christmann M (2007a) Efficient Synthesis and
Resolution of Pyrrolizidines. Angew Chem Int Ed 46:2883–2886
de Figueiredo RM, Voith M, Fröhlich R, Christmann M (2007b) Synthesis of
a Malimide Analogue of the Telomerase Inhibitor UCS1025A Using a Dianionic Aldol Strategy. Synlett 391–394
Deschka G, Dimic N (1986) Cameraria ohridella sp. n. (Lep., Lithocolletidae)
from Macedonia, Yugoslavia. Acta Ent Jugosl 22:11–23
Doi T, Yoshida T, Shin-ya K, Takahashi T (2006) Total Synthesis of (R)-Telomestatin. Org Lett 8:4165–4167
El-Sayed AM, Gödde J, Witzgall P, Arn H (1999) Characterization of pheromone blend for grapevine moth, Lobesia botrana by using flight track recording. J Chem Ecol 25:389–400
M. Christmann
5
Conclusion
We have shown organocatalysis to be a powerful tool for the synthesis
of drugs and natural products. Our work and that of others have clearly
demonstrated that organocatalytic strategies can cut down the total number of synthetic operations. As organocatalysts are usually non-toxic,
air- and moisture-stable and often available from renewable sources,
they are destined to have an impact on the development of future sustainable chemical processes.
Acknowledgements. I would like to thank the Fonds der Chemischen Industrie for a Liebig fellowship, the Deutsche Forschungsgemeinschaft for funding
(SPP1179 Organokatalyse) and Prof. Dieter Enders for his encouragement and
support.
References
Agatsuma T, Akama T, Nara S, Matsumiya S, Nakai R, Ogawa H, Otaki S, Ikeda
S, Saitoh Y, Kanda Y (2002) UCS1025A and B, new antitumor antibiotics
from the fungus Acremonium species. Org Lett 4:4387–4390
de Figueiredo RM, Christmann M (2007) Organocatalytic synthesis of drugs
and bioactive natural products. Eur J Org Chem 2575–2600
de Figueiredo RM, Fröhlich R, Christmann M (2006) N,N -Carbonyldiimidazole-mediated cyclization of amino alcohols to substituted azetidines and
other N-heterocycles. J Org Chem 71:4147–4154
de Figueiredo RM, Berner R, Julis J, Liu T, Türp D, Christmann M (2007)
Bidirectional, organocatalytic synthesis of lepidopteran sex pheromones.
J Org Chem 72:640–642
de Figueiredo RM, Fröhlich R, Christmann M (2007a) Efficient Synthesis and
Resolution of Pyrrolizidines. Angew Chem Int Ed 46:2883–2886
de Figueiredo RM, Voith M, Fröhlich R, Christmann M (2007b) Synthesis of
a Malimide Analogue of the Telomerase Inhibitor UCS1025A Using a Dianionic Aldol Strategy. Synlett 391–394
Deschka G, Dimic N (1986) Cameraria ohridella sp. n. (Lep., Lithocolletidae)
from Macedonia, Yugoslavia. Acta Ent Jugosl 22:11–23
Doi T, Yoshida T, Shin-ya K, Takahashi T (2006) Total Synthesis of (R)-Telomestatin. Org Lett 8:4165–4167
El-Sayed AM, Gödde J, Witzgall P, Arn H (1999) Characterization of pheromone blend for grapevine moth, Lobesia botrana by using flight track recording. J Chem Ecol 25:389–400