Biomimetic Organocatalytic C–C-Bond Formations
65
Scheme 11. Asymmetric organocatalytic synthesis of protected amino sugars
39–43
This protocol led to the diamine 46, which also represents a protected
amino sugar (2,4-diamino-2,4-dideoxy-l-xylose). Interestingly, the direct reductive amination of 47 was followed by in situ cyclization to
afford the lactam 48 as the major diastereomer.
Our efficient asymmetric catalytic approach provides a viable alternative to the conventional, relatively elaborate, and less flexible methods
65
Scheme 11. Asymmetric organocatalytic synthesis of protected amino sugars
39–43
This protocol led to the diamine 46, which also represents a protected
amino sugar (2,4-diamino-2,4-dideoxy-l-xylose). Interestingly, the direct reductive amination of 47 was followed by in situ cyclization to
afford the lactam 48 as the major diastereomer.
Our efficient asymmetric catalytic approach provides a viable alternative to the conventional, relatively elaborate, and less flexible methods